Search by BoMiProt ID - Bomi348


Primary Information

BoMiProt ID Bomi348
Protein Name Signal peptidase complex catalytic subunit SEC11A
Organism Bos taurus
Uniprot IDP67810
Milk FractionMFGM
Ref Sequence ID NP_776890.1
Aminoacid Length 179
Molecular Weight 20625
FASTA Sequence Download
Gene Name SEC11A
Gene ID 282078
Protein Existence Status Reviewed: Experimental evidence at transcript level

Secondary Information

Presence in other biological fluids/tissue/cells located in the endoplasmic reticulum
Protein Function secretory, lysosomal and some membrane proteins contain a signal sequence that targets polysomes synthesizing them to the endoplasmic reticulum and is endoproteolytically cleaved by signal peptidase during translocation of the nascent chains; enzyme responsible for removing the NHz-terminal hydrophobic signal peptidase portions of newly synthesized secretory proteins during their translocation across the membrane
Biochemical Properties Purified microsomal signal peptidase from canine pancrease consists of six polypeptides with apparent molecular masses of 12, 18, 21, 22, 23, and 25 kDa; phospholipid is required for activity of the enzyme; solubilized with detergents
PTMs glycosylated
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction 1TMH; (18-36)
Bibliography 1. Uchida, M., Watanabe, Y. and Fujimoto, Y. (1986) ‘Is phospholipid a required cofactor for the activity of mammalian signal peptidase?’, FEBS Letters, 200(2), pp. 343–346. doi: 10.1016/0014-5793(86)81165-6.
2. Evans, E. A., Gilmore, R. and Blobel, G. (1986) ‘Purification of microsomal signal peptidase as a complex.’, Proceedings of the National Academy of Sciences, 83(3), pp. 581–585. doi: 10.1073/pnas.83.3.581.