Primary Information |
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BoMiProt ID | Bomi348 |
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Protein Name | Signal peptidase complex catalytic subunit SEC11A |
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Organism | Bos taurus |
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Uniprot ID | P67810 |
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Milk Fraction | MFGM |
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Ref Sequence ID | NP_776890.1 |
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Aminoacid Length | 179 |
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Molecular Weight | 20625 |
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FASTA Sequence |
Download |
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Gene Name | SEC11A |
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Gene ID | 282078 |
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Protein Existence Status | Reviewed: Experimental evidence at transcript level |
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Secondary Information |
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Presence in other biological fluids/tissue/cells | located in the endoplasmic
reticulum |
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Protein Function | secretory, lysosomal and some membrane proteins
contain a signal sequence that targets polysomes synthesizing
them to the endoplasmic reticulum and is endoproteolytically
cleaved by signal peptidase during translocation
of the nascent chains; enzyme responsible for
removing the NHz-terminal hydrophobic signal
peptidase portions of newly synthesized secretory
proteins during their translocation across the membrane
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Biochemical Properties | Purified
microsomal signal peptidase from canine pancrease consists of six polypeptides with
apparent molecular masses of 12, 18, 21, 22, 23, and 25 kDa; phospholipid is required for activity
of the enzyme; solubilized with
detergents |
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PTMs | glycosylated |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
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Predicted Disorder Regions | NA |
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DisProt Annotation | |
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TM Helix Prediction | 1TMH; (18-36) |
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Bibliography | 1. Uchida, M., Watanabe, Y. and Fujimoto, Y. (1986) ‘Is phospholipid a required cofactor for the activity of mammalian signal peptidase?’, FEBS Letters, 200(2), pp. 343–346. doi: 10.1016/0014-5793(86)81165-6. 2. Evans, E. A., Gilmore, R. and Blobel, G. (1986) ‘Purification of microsomal signal peptidase as a complex.’, Proceedings of the National Academy of Sciences, 83(3), pp. 581–585. doi: 10.1073/pnas.83.3.581. |