Search by BoMiProt ID - Bomi3460


Primary Information

BoMiProt ID Bomi3460
Protein Name 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4/PLC-85/Phosphoinositide phospholipase C-delta-4/Phospholipase C-delta-2/Phospholipase C-delta-4
Organism Bos taurus
Uniprot IdP21671
Milk FractionWhey,MFGM
Ref Sequence Id NP_001039954.1
Aminoacid Length 791
Molecular Weight 90581
Fasta Sequence https://www.uniprot.org/uniprot/P21671.fasta
Gene Name PLCD4/PLCD2
Gene Id 540771
Protein Existence Status reviewed

Secondary Information

Protein Function PLC delta 4 is expressed in nucleus in response to mitogenic stimulation and plays important roles in cell growth as one of the early genes expressed during the transition from G1- to S-phase in the cell cycle.PLC delta 4 mRNA is expressed more remarkably in regenerating liver than in normal resting liver.Acrosome reaction in sperm.
Biochemical Properties Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca2+ from intracellular stores.PLC isozymes contain catalytic X and Y domains as well as various regulatory domains, including the C2 domain,EF-Hand domain and pleckstrin homology domain(PH).
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
na
Predicted Disorder Regions 444-478
DisProt Annotation
TM Helix Prediction no TM helices
Additional Comments To date, four PLCδ isozymes have been reported. It has been suggested that PLCδ1 is involved in Alzheimer’s disease and is essential for hypertension.
Bibliography 1.Liu N, Fukami K, Yu H, Takenawa T. A new phospholipase C delta 4 is induced at S-phase of the cell cycle and appears in the nucleus. J Biol Chem. 1996 Jan 5;271(1):355-60. doi: 10.1074/jbc.271.1.355. PMID: 8550586. 2.Irino Y, Cho H, Nakamura Y, Nakahara M, Furutani M, Suh PG, Takenawa T, Fukami K. Phospholipase C delta-type consists of three isozymes: bovine PLCdelta2 is a homologue of human/mouse PLCdelta4. Biochem Biophys Res Commun. 2004 Jul 23;320(2):537-43. doi: 10.1016/j.bbrc.2004.05.206. PMID: 15219862.