Search by BoMiProt ID - Bomi3454


Primary Information

BoMiProt ID Bomi3454
Protein Name 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha/1-acylglycerol-3-phosphate O-acyltransferase 1/1-AGP acyltransferase 1/1-AGPAT 1/Lysophosphatidic acid acyltransferase alpha(LPAAT-alpha)
Organism Bos taurus
Uniprot IdQ95JH2
Milk FractionWhey,MFGM
Ref Sequence Id NP_803484.1
Aminoacid Length 287
Molecular Weight 32005
Fasta Sequence https://www.uniprot.org/uniprot/Q95JH2.fasta
Gene Name AGPAT1
Gene Id 282137
Protein Existence Status reviewed

Secondary Information

Protein Function Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
na
Predicted Disorder Regions 1 predicted disordered segment; (269-287)
DisProt Annotation
TM Helix Prediction 3 TMHs;(3-25),(40-58) & (129-147)
Additional Comments small interference RNA-mediated knockdown of AGPAT1 expression prevents the induction of myogenin, a key transcriptional activator of the myogenic program, and inhibits the expression of myosin heavy chain. This effect is rescued by transfection with AGPAT1 but not AGPAT2.
Bibliography Subauste AR, Elliott B, Das AK, Burant CF. A role for 1-acylglycerol-3-phosphate-O-acyltransferase-1 in myoblast differentiation. Differentiation. 2010 Sep-Oct;80(2-3):140-6. doi: 10.1016/j.diff.2010.05.006. Epub 2010 Jun 19. PMID: 20561744; PMCID: PMC3449212.