Search by BoMiProt ID - Bomi3443


Primary Information

BoMiProt ID Bomi3443
Protein Name [Protein ADP-ribosylarginine] hydrolase/ADP-ribose-L-arginine cleaving enzyme
Organism Bos taurus
Uniprot IdQ32KR8
Milk FractionExosomes
Ref Sequence Id NP_001033643.1
Aminoacid Length 353
Molecular Weight 39152
Fasta Sequence https://www.uniprot.org/uniprot/Q32KR8.fasta
Gene Name ADPRH
Gene Id 525738
Protein Existence Status Reviewed

Secondary Information

Presence in other biological fluids/tissue/cells liver
Protein Function Participates in ADP-ribosylation cycle during the release of ADP-ribose and regenerate an unmodified protein.It  acts as an arginine mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to arginine residues on proteins.
Biochemical Properties Binds 2 magnesium ions per subunit.H2O + Nω-(ADP-D-ribosyl)-L-arginyl-[protein] = ADP-D-ribose + L-arginyl-[protein] ADP-ribosylarginine hydrolases differ in their dithiothreitol (DTT) requirements: the rat and mouse enzymes require DTT for maximal activity, while the calf, guinea pig, and human hydrolases are DTT-independent.
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
na
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Bibliography 1.Takada T, Iida K, Moss J. Cloning and site-directed mutagenesis of human ADP-ribosylarginine hydrolase. J Biol Chem. 1993 Aug 25;268(24):17837-43. PMID: 8349667.