Primary Information
BoMiProt ID	Bomi3368
Protein Name	hepatoma-derived growth factor
Organism	Bos taurus
Uniprot ID	Q9XSK7
Milk Fraction	Whey
Ref Sequence ID	NP_787026.1
Aminoacid Length	239
Molecular Weight	26604
FASTA Sequence	Download
Gene Name	HDGF
Gene ID	327953
Protein Existence Status	Reviewed: Experimental evidence at transcript level
Secondary Information
Protein Function	Hepatoma-derived growth factor (HDGF) has been delineated to participate in hepatic fibrosis and liver carcinogenesis.
PTMs	Phosphorylation at Ser-165 and Thr residues,N6-acetylation at Lysine,Disulfide bond and Isopeptide bond formation, Ubl conjugation,Sumoylation
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation
Predicted Disorder Regions	69-239
DisProt Annotation
TM Helix Prediction	No TM helices
Significance of PTMs	Sumoylation prevents binding to chromatin.Phosphorylation at Ser-165 is likely to be required for secretion.
Bibliography	1.Wang EM, Hu TH, Huang CC, Chang YC, Yang SM, Huang ST, Wu JC, Ma YL, Chan HH, Liu LF, Lu WB, Kung ML, Wen ZH, Wang JC, Ko CY, Tsai WL, Chu TH, Tai MH. Hepatoma-derived growth factor participates in concanavalin A-induced hepatitis. FASEB J. 2020 Dec;34(12):16163-16178. doi: 10.1096/fj.202000511RR. Epub 2020 Oct 15. PMID: 33063394.