Search by BoMiProt ID - Bomi3331


Primary Information

BoMiProt ID Bomi3331
Protein Name transgelin-3 isoform X1
Organism Bos taurus
Uniprot IDQ3ZBY2
Milk FractionWhey
Ref Sequence ID NP_001029671.1
Aminoacid Length 199
Molecular Weight 22485
FASTA Sequence Download
Gene Name TAGLN3
Gene ID 515562
Protein Existence Status Reveiwed:Experimental evidence at transcript level

Secondary Information

Protein Function  Transgelin-3 (T-3), belongs to the family of actin-binding proteins (ABPs) that can alter the structure and morphology of the cytoskeleton.This protein function by regulating migration, proliferation and apoptosis in many different cancers.
Biochemical Properties There are three isoforms in the transgelin family based on the isoelectric point: T-1 (SM22α), T-2 (SM22β), and T-3 (SM22γ), and they differ in cell type expression. As a member of the calponin protein family, transgelin contains a single C-terminal calponin-like module (CLIK23) and an N-terminal calponin-homolog (CH) domain comprising six α-helices that interact with the actin complex.Transgelin, with its type-3 CH domain, binds to actin upon interacting with extracellular signal-regulated kinase (ERK)
PTMs Phosphorylation at Serine
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
Predicted Disorder Regions (178-199)
DisProt Annotation
TM Helix Prediction No TM helices
Additional Comments T-3 is only expressed in neurons and is not associated with CRC (Colorectal cancer). 
Bibliography 1.Liu J, Zhang Y, Li Q, Wang Y. Transgelins: Cytoskeletal Associated Proteins Implicated in the Metastasis of Colorectal Cancer. Front Cell Dev Biol. 2020 Oct 7;8:573859. doi: 10.3389/fcell.2020.573859. PMID: 33117801; PMCID: PMC7575706. 2.Proteomic analysis of rat hippocampus and frontal cortex after chronic treatment with fluoxetine or putative novel antidepressants: CRF1 and NK1 receptor antagonists.Carboni L, Vighini M, Piubelli C, Castelletti L, Milli A, Domenici E.Eur Neuropsychopharmacol. 2006 Oct; 16(7):521-37. 3.Natural feeding influences protein expression in the dogfish shark rectal gland: A proteomic analysis. Dowd WW, Wood CM, Kajimura M, Walsh PJ, Kültz D.Comp Biochem Physiol Part D Genomics Proteomics. 2008 Mar; 3(1):118-27. 4.Comparative proteomic profiling in squamous cell carcinoma of the uterine cervix. Fukushima C, Murakami A, Yoshitomi K, Sueoka K, Nawata S, Nakamura K, Sugino N.Proteomics Clin Appl. 2011 Apr; 5(3-4):133-40. 5.Fibroblast transgelin and smooth muscle SM22alpha are the same protein, the expression of which is down-regulated in many cell lines.Lawson D, Harrison M, Shapland C.Cell Motil Cytoskeleton. 1997; 38(3):250-7. 6.Mutagenesis analysis of human SM22: characterization of actin binding. Fu Y, Liu HW, Forsythe SM, Kogut P, McConville JF, Halayko AJ, Camoretti-Mercado B, Solway J.J Appl Physiol (1985). 2000 Nov; 89(5):1985-90. 7.Crystal structure of human transgelin.Li M, Li S, Lou Z, Liao X, Zhao X, Meng Z, Bartlam M, Rao Z.J Struct Biol. 2008 May; 162(2):229-36. 8.Transgelin-1 (SM22α) interacts with actin stress fibers and podosomes in smooth muscle cells without using its actin binding site.Matsui TS, Ishikawa A, Deguchi S.Biochem Biophys Res Commun. 2018 Nov 2; 505(3):879-884.