Biochemical Properties | There are three isoforms in the transgelin family based on the isoelectric point: T-1 (SM22α), T-2 (SM22β), and T-3 (SM22γ), and they differ in cell type expression. As a member of the calponin protein family, transgelin contains a single C-terminal calponin-like module (CLIK23) and an N-terminal calponin-homolog (CH) domain comprising six α-helices that interact with the actin complex.Transgelin, with its type-3 CH domain, binds to actin upon interacting with extracellular signal-regulated kinase (ERK) |
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