Primary Information |
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BoMiProt ID | Bomi3326 |
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Protein Name | endoplasmic reticulum resident protein 44 |
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Organism | Bos taurus |
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Uniprot ID | Q3T0L2 |
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Milk Fraction | Whey |
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Ref Sequence ID | NP_001030204.1 |
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Aminoacid Length | 406 |
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Molecular Weight | 46836 |
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FASTA Sequence |
Download |
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Gene Name | ERP44 |
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Gene ID | 506157 |
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Protein Existence Status | Reviewed: Experimental evidence at transcript level |
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Secondary Information |
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Protein Function | Endoplasmic reticulum (ER) resident protein 44 (ERp44) is a member of the protein disulfide isomerase family, is induced during ER stress, and may be involved in regulating Ca(2+) homeostasis. |
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Biochemical Properties | The ER resident protein 44 (ERp44; originally referred to as Txnd4) is a UPR‐induced ER protein of the protein disulphide isomerase (PDI) family.ERp44 may regulate oxidative protein folding and client protein homeostasis through thiol‐mediated protein retention in the ER.ERp44 has been shown to inhibit Ca2+ release through binding and inactivating inositol trisphosphate receptor 1 (IP3R1).ERp44 binds to the third luminal loop of the IP3R1, which is the home to structural differences between IP3R subtypes, suggesting that the interaction of ERp44 might be specific for type 1 IP3R. |
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PTMs | Disulfide bond formation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
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Predicted Disorder Regions | 328-372,373-388 |
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DisProt Annotation | |
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TM Helix Prediction | No TM helices |
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Additional Comments | Deletion of ERp44 in mouse and zebrafish caused significant embryonic lethality, abnormal heart development, altered Ca(2+) dynamics, reactive oxygen species generation, activated ER stress gene profiles, and apoptotic cell death. |
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Bibliography | 1.Wang DY, Abbasi C, El-Rass S, Li JY, Dawood F, Naito K, Sharma P, Bousette N, Singh S, Backx PH, Cox B, Wen XY, Liu PP, Gramolini AO. Endoplasmic reticulum resident protein 44 (ERp44) deficiency in mice and zebrafish leads to cardiac developmental and functional defects. J Am Heart Assoc. 2014 Oct 20;3(5):e001018. doi: 10.1161/JAHA.114.001018. PMID: 25332179; PMCID: PMC4323785. |