Search by BoMiProt ID - Bomi332


Primary Information

BoMiProt ID Bomi332
Protein Name Solute carrier family 13 (Sodium-dependent dicarboxylate transporter), member 2
Organism Bos taurus
Uniprot IdQ3SYV8
Milk FractionExosome
Ref Sequence Id NP_001029406.1
Amino Acid Lenth 592
Molecular Weight 64980
Fasta Sequence https://www.uniprot.org/uniprot/Q3SYV8.fasta
Gene Name SLC13A2
Gene Id 505069
Protein Existence Status Unreviewed: Experimental evidence at transcript level

Secondry Information

Presence in other biological fluids/tissue/cells NaDC1 is located at the brush border (apical) membrane of renal proximal tubular and intestinal epithelial cells ; NaDC3 is primarily expressed at the basolateral membrane of renal proximal tubular epithelial cells, expressed in liver, placenta and brain
Protein Function Responsible for transport of Krebs cycle intermediates and may involve in regulation of aging and life span; involves in regulation of urinary citrate, which acts as a calcium chelator to inhibit the formation of kidney stones
Biochemical Properties contains 11 or 12 hydrophobic transmembrane (TM) domains; based on their substrate affinity, the transporters are classified into two categories: low-affinity NaDC1 (SDCT1) and high-affinity NaDC3 (SDCT2)
Significance in milk nutrient transport systems for milk precursors and constituents
Bibliography 1. Bai, X.-Y. et al. (2007) ‘Membrane topology structure of human high-affinity, sodium-dependent dicarboxylate transporter’, The FASEB Journal, 21(10), pp. 2409–2417. doi: 10.1096/fj.06-7652com.
2. Bai, X. et al. (2004) ‘Expression of EGFP/SDCT1 fusion protein, subcellular localization signal analysis, tissue distribution and electrophysiological function study.’, Science in China. Series C, Life sciences, 47(6), pp. 530–9. Available at: http://www.ncbi.nlm.nih.gov/pubmed/15620109 (Accessed: 3 October 2019).