Primary Information |
|---|
| BoMiProt ID | Bomi33 |
|---|
| Protein Name | Peptidoglycan recognition protein 1 |
|---|
| Organism | Bos taurus |
|---|
| Uniprot Id | Q8SPP7 |
|---|
| Milk Fraction | Whey |
|---|
| Ref Sequence Id | NP_776998.1 |
|---|
| Aminoacid Length | 190 |
|---|
| Molecular Weight | 21063 |
|---|
| Fasta Sequence | https://www.uniprot.org/uniprot/Q8SPP7.fasta |
|---|
| Gene Name | PGLYRP1 |
|---|
| Gene Id | 282305 |
|---|
| Protein Existence Status | Reviewed: Experimental evidence at protein level |
|---|
Secondary Information |
|---|
| Presence in other biological fluids/tissue/cells | neutrophils, eosinophil, bone marrow, fetal liver |
|---|
| Protein Function | pattern recognition molecules of innate immunity; bind bacterial molecules and kill in peptidoglycan independent manner; recognizes
multiple microbial components |
|---|
| Biochemical Properties | highest affinity for lipopolysaccharide; significant affinity for lipotechoic acid and little for peptidoglycan in
killing inhibition assays; MgCl2 or CaCl2 as low as 0.8 mM ablate bPGRP-S-mediated killing
of S. typhimurium; bPGRP-S has a serine substitution at a cysteine residue
predicted to stabilize a zinc ion; PGRP in camel ripe and porcine colostral milk
is a 19-kDa monomeric protein; |
|---|
| Significance in milk | As found in camel milk it exhibits udder protection; control lactic acid bacteria; upregulated in cases of mastitis; avidly bound
to lactic acid bacteria, and the protein was markedly
upregulated in the case of streptococcal infection; |
|---|
Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| |
|---|
| Predicted Disorder Regions | NA |
|---|
| DisProt Annotation | |
|---|
| TM Helix Prediction | No TM helices |
|---|
| Additional Comments | In mammals, PRPs are differentially expressed in
the bone marrow, liver, and esophagus where they are likely to
play a role in recognition of bacteria |
|---|
| Bibliography | 1. Kappeler, S. R., Heuberger, C., Farah, Z., & Puhan, Z. (2004). Expression of the peptidoglycan recognition protein, PGRP, in the lactating mammary gland. Journal of Dairy Science, 87(8), 2660–2668. https://doi.org/10.3168/jds.S0022-0302(04)73392-5.
2. Dziarski, R. (2004). Peptidoglycan recognition proteins (PGRPs). Molecular Immunology, 40(12), 877–886. https://doi.org/10.1016/j.molimm.2003.10.011.
3. Tydell, C. C., Yuan, J., Tran, P., & Selsted, M. E. (2006). Bovine peptidoglycan recognition protein-S: antimicrobial activity, localization, secretion, and binding properties. Journal of Immunology (Baltimore, Md. : 1950), 176(2), 1154–1162. https://doi.org/10.4049/jimmunol.176.2.1154. |
|---|
