Primary Information |
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BoMiProt ID | Bomi3249 |
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Protein Name | lumican isoform X1 |
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Organism | Bos taurus |
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Uniprot ID | Q05443 |
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Milk Fraction | Whey |
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Ref Sequence ID | NP_776359.1 |
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Aminoacid Length | 342 |
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Molecular Weight | 38756 |
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FASTA Sequence |
Download |
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Gene Name | LUM |
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Gene ID | 280847 |
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Protein Existence Status | Reviewed: Experimental evidence at protein level |
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Secondary Information |
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Protein Function | lumican acts as a cancer prognosis marker, chemoresistance regulator, and cancer therapy target. |
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Biochemical Properties | Lumican, a class II SLRP, has a 38 kDa protein core exhibiting four distinct regions: a 16 amino acid peptide, a negatively charged N-terminal region containing tyrosine sulfate and disulfide bonds, a 6–10 LRR motifs characterized by common molecular architecture that supports protein interactions, and a C-terminal region consisting of two conserved cysteine residues. |
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PTMs | Disulfide bond formation,N-Linked Glycosylation at Asn, Phosphorylation at Ser, Sulfation at Tyr |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
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Predicted Disorder Regions | NA |
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DisProt Annotation | |
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TM Helix Prediction | No TM helices |
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Significance of PTMs | Most SLRP family members undergo different post-translational glycosylation and are competent to regulate signal transduction mechanisms, and affect various cellular functions, like proliferation, migration, and differentiation. |
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Bibliography | 1.Giatagana EM, Berdiaki A, Tsatsakis A, Tzanakakis GN, Nikitovic D. Lumican in Carcinogenesis-Revisited. Biomolecules. 2021 Sep 6;11(9):1319. doi: 10.3390/biom11091319. PMID: 34572532; PMCID: PMC8466546. 2.Onnerfjord P, Heathfield TF, Heinegård D. Identification of tyrosine sulfation in extracellular leucine-rich repeat proteins using mass spectrometry. J Biol Chem. 2004 Jan 2;279(1):26-33. doi:10.1074/jbc.M308689200. Epub 2003 Oct 8. PMID: 14551184. 3.Small leucine rich proteoglycans, a novel link to osteoclastogenesis.Kram V, Kilts TM, Bhattacharyya N, Li L, Young MF Sci Rep. 2017 Oct 3;7(1):12627. 4.Proteoglycans in the Pathogenesis of Hormone-Dependent Cancers: Mediators and Effectors.Tzanakakis G, Giatagana EM, Kuskov A, Berdiaki A, Tsatsakis AM, Neagu M, Nikitovic D Cancers (Basel).2020 Aug 24; 12(9):. 5. The Role of IGF/IGF-IR-Signaling and Extracellular Matrix Effectors in Bone Sarcoma Pathogenesis.Tzanakakis GN, Giatagana EM, Berdiaki A, Spyridaki I, Hida K, Neagu M, Tsatsakis AM, Nikitovic D Cancers (Basel). 2021 May 19; 13(10):. |