Primary Information |
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| BoMiProt ID | Bomi3236 |
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| Protein Name | transforming growth factor-beta-induced protein |
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| Organism | Bos taurus |
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| Uniprot ID | P55906 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001192331.1 |
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| Aminoacid Length | 683 |
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| Molecular Weight | 74408 |
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| FASTA Sequence |
Download |
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| Gene Name | TGFBI |
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| Gene ID | 539596 |
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| Protein Existence Status | Reveiwed:Experimental evidence at protein level |
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Secondary Information |
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| Protein Function | Transforming growth factor-beta-induced protein (TGFBIp)/beta ig-h3 is a 68-kDa extracellular matrix protein that is functionally associated with the adhesion, migration, proliferation, and differentiation of various cells. |
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| Biochemical Properties | The fasciclin 1 domains of TGFBIp are mainly responsible for the activation of platelets. |
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| PTMs | Disulfide bond formation,Attachment of Gamma-carboxyglutamic acid, Phosphorylation at Ser |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Significance of PTMs | Gamma-carboxyglutamated; gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation; this may be required for calcium binding.The EMI domain contains 2 expected intradomain disulfide bridges (Cys-49-Cys85 and Cys-84-Cys-97) and one unusual interdomain disulfide bridge to the second FAS1 domain (Cys-74-Cys-339). |
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| Bibliography | Kim HJ, Kim PK, Bae SM, Son HN, Thoudam DS, Kim JE, Lee BH, Park RW, Kim IS. Transforming growth factor-beta-induced protein (TGFBIp/beta ig-h3) activates platelets and promotes thrombogenesis. Blood. 2009 Dec 10;114(25):5206-15. doi: 10.1182/blood-2009-03-212415. PMID: 19738031. |
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