Primary Information |
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BoMiProt ID | Bomi3232 |
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Protein Name | Cyclin-dependent kinase 1 |
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Organism | Bos taurus |
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Uniprot ID | P48734 |
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Milk Fraction | Whey |
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Ref Sequence ID | NP_776441.1 |
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Aminoacid Length | 297 |
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Molecular Weight | 34025 |
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FASTA Sequence |
Download |
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Gene Name | CDK1 |
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Gene ID | 281061 |
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Protein Existence Status | Reveiwed:Experimental evidence at transcript level |
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Secondary Information |
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Protein Function | CDK1 influences the initiation of protein synthesis, promotes the activity of specific translational initiation factors and affects the functioning of a subset of elongation factors. |
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PTMs | Acetylation, Isopeptide bond formation,Phosphorylation at Thr-161, Ubl conjugation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
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Predicted Disorder Regions | NA |
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DisProt Annotation | |
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TM Helix Prediction | No TM helices |
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Significance of PTMs | Phosphorylation at Thr-161 by CAK/CDK7 activates kinase activity. Phosphorylation at Thr-14 and Tyr-15 by PKMYT1 prevents nuclear translocation. Phosphorylation at Tyr-15 by WEE1 and WEE2 inhibits the protein kinase activity and acts as a negative regulator of entry into mitosis (G2 to M transition).Phosphorylation by PKMYT1 and WEE1 takes place during mitosis to keep CDK1-cyclin-B complexes inactive until the end of G2. |
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Additional Comments | CDK1, CCNB1 and CCNB2 could be regarded as potential diagnostic and prognostic biomarkers for HCC, and CDK1 might serve as a promising therapeutic target for lycorine against HCC. |
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Bibliography | 1.Kalous J, Jansová D, Šušor A. Role of Cyclin-Dependent Kinase 1 in Translational Regulation in the M-Phase. Cells. 2020 Jun 27;9(7):1568. doi: 10.3390/cells9071568. PMID: 32605021; PMCID: PMC7408968. 2.Yin S, Yang S, Luo Y, Lu J, Hu G, Wang K, Shao Y, Zhou S, Koo S, Qiu Y, Wang T, Yu H. Cyclin-dependent kinase 1 as a potential target for lycorine against hepatocellular carcinoma. Biochem Pharmacol. 2021 Nov;193:114806. doi: 10.1016/j.bcp.2021.114806. Epub 2021 Oct 18. PMID: 34673013. |