Search by BoMiProt ID - Bomi3232


Primary Information

BoMiProt ID Bomi3232
Protein Name Cyclin-dependent kinase 1
Organism Bos taurus
Uniprot IDP48734
Milk FractionWhey
Ref Sequence ID NP_776441.1
Aminoacid Length 297
Molecular Weight 34025
FASTA Sequence Download
Gene Name CDK1
Gene ID 281061
Protein Existence Status Reveiwed:Experimental evidence at transcript level

Secondary Information

Protein Function CDK1 influences the initiation of protein synthesis, promotes the activity of specific translational initiation factors and affects the functioning of a subset of elongation factors.
PTMs Acetylation, Isopeptide bond formation,Phosphorylation at Thr-161, Ubl conjugation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Significance of PTMs Phosphorylation at Thr-161 by CAK/CDK7 activates kinase activity. Phosphorylation at Thr-14 and Tyr-15 by PKMYT1 prevents nuclear translocation. Phosphorylation at Tyr-15 by WEE1 and WEE2 inhibits the protein kinase activity and acts as a negative regulator of entry into mitosis (G2 to M transition).Phosphorylation by PKMYT1 and WEE1 takes place during mitosis to keep CDK1-cyclin-B complexes inactive until the end of G2.
Additional Comments  CDK1, CCNB1 and CCNB2 could be regarded as potential diagnostic and prognostic biomarkers for HCC, and CDK1 might serve as a promising therapeutic target for lycorine against HCC.
Bibliography 1.Kalous J, Jansová D, Šušor A. Role of Cyclin-Dependent Kinase 1 in Translational Regulation in the M-Phase. Cells. 2020 Jun 27;9(7):1568. doi: 10.3390/cells9071568. PMID: 32605021; PMCID: PMC7408968. 2.Yin S, Yang S, Luo Y, Lu J, Hu G, Wang K, Shao Y, Zhou S, Koo S, Qiu Y, Wang T, Yu H. Cyclin-dependent kinase 1 as a potential target for lycorine against hepatocellular carcinoma. Biochem Pharmacol. 2021 Nov;193:114806. doi: 10.1016/j.bcp.2021.114806. Epub 2021 Oct 18. PMID: 34673013.