Search by BoMiProt ID - Bomi3206


Primary Information

BoMiProt ID Bomi3206
Protein Name Protein disulfide-isomerase
Organism Bos taurus
Uniprot IDP05307
Milk FractionWhey
Ref Sequence ID NP_776560.1
Aminoacid Length 510
Molecular Weight 57266
FASTA Sequence Download
Gene Name P4HB
Gene ID 281373
Protein Existence Status Reveiwed:Experimental evidence at protein level

Secondary Information

Protein Function Protein disulfide isomerase (PDI) is a 57-kDa oxidoreductase that facilitates cysteine thiol reactions inside and outside the cell. It mediates reduction or oxidation of protein disulfide bonds, thiol/disulfide exchange reactions, and transfer of NO from one protein thiol to another.
PTMs N6-Acetylation at Lys, Disulfide bond formation, Phosphorylation at Ser
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
Predicted Disorder Regions 148-149,361-363,475-510
DisProt Annotation
TM Helix Prediction No TM helices
Additional Comments  Novel small-molecule PDI inhibitors have been developed and are being evaluated as antithrombotics in clinical trials. 
Bibliography Chiu J, Passam F, Butera D, Hogg PJ. Protein Disulfide Isomerase in Thrombosis. Semin Thromb Hemost. 2015 Oct;41(7):765-73. doi: 10.1055/s-0035-1564047. Epub 2015 Sep 26. PMID: 26408919.