Primary Information |
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BoMiProt ID | Bomi3206 |
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Protein Name | Protein disulfide-isomerase |
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Organism | Bos taurus |
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Uniprot ID | P05307 |
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Milk Fraction | Whey |
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Ref Sequence ID | NP_776560.1 |
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Aminoacid Length | 510 |
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Molecular Weight | 57266 |
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FASTA Sequence |
Download |
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Gene Name | P4HB |
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Gene ID | 281373 |
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Protein Existence Status | Reveiwed:Experimental evidence at protein level |
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Secondary Information |
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Protein Function | Protein disulfide isomerase (PDI) is a 57-kDa oxidoreductase that facilitates cysteine thiol reactions inside and outside the cell. It mediates reduction or oxidation of protein disulfide bonds, thiol/disulfide exchange reactions, and transfer of NO from one protein thiol to another. |
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PTMs | N6-Acetylation at Lys, Disulfide bond formation, Phosphorylation at Ser |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
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Predicted Disorder Regions | 148-149,361-363,475-510 |
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DisProt Annotation | |
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TM Helix Prediction | No TM helices |
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Additional Comments | Novel small-molecule PDI inhibitors have been developed and are being evaluated as antithrombotics in clinical trials. |
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Bibliography | Chiu J, Passam F, Butera D, Hogg PJ. Protein Disulfide Isomerase in Thrombosis. Semin Thromb Hemost. 2015 Oct;41(7):765-73. doi: 10.1055/s-0035-1564047. Epub 2015 Sep 26. PMID: 26408919. |