Search by BoMiProt ID - Bomi318


Primary Information

BoMiProt ID Bomi318
Protein Name Vitamin K-dependent protein C (Fragment)
Organism Bos taurus
Uniprot IDP00745
Milk FractionWhey
Aminoacid Length 456
Molecular Weight 51409
FASTA Sequence Download
Gene Name PROC
Protein Existence Status Reviewed: Experimental evidence at protein level

Secondary Information

Protein Function vitamin-K-dependent plasma zymogen; potently inhibits coagulation by inactivating factors V and VIII, and it facilitates fibrinolysis in vivo; Activated protein-C functions as an anticoagulant by inactivating factor V and factor V1II; terminal enzyme in the coagulation pathway and directly responsible for factor V and VIII inactivation
Biochemical Properties As found in humans and bovines, two-chain, disulfide-linked protein; thrombin activates human protein-C by a single cleavage that appears to be between Arg 12 and Leu 13 of the heavy chain which is inhibited at high physiologic Ca2+; The light chain contains ɣ-carboxyglutamic acid residues that are involved in Ca2+-dependent membrane association; light chain of bovine protein-C also contains one residue of fl-hydroxyaspartic acid at position 71; Activated protein C and protein S form an anticoagulant complex on cell surfaces that inactivates two of the regulatory proteins of coagulation, factors Va and VIlla;
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Bibliography 1. Kisiel, W. (1979) ‘Human Plasma Protein C’, Journal of Clinical Investigation, 64(3), pp. 761–769. doi: 10.1172/JCI109521.
2. Drakenberg, T. et al. (1983) ‘beta-Hydroxyaspartic acid in vitamin K-dependent protein C.’, Proceedings of the National Academy of Sciences, 80(7), pp. 1802–1806. doi: 10.1073/pnas.80.7.1802.
3. Vehar, G. A. and Davie, E. W. (1980) ‘Preparation and properties of bovine factor VIII (antihemophilic factor)’, Biochemistry, 19(3), pp. 401–410. doi: 10.1021/bi00544a001.