Primary Information |
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BoMiProt ID | Bomi305 |
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Protein Name | DNA mismatch repair protein Msh2 |
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Organism | Bos taurus |
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Uniprot ID | Q3MHE4 |
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Milk Fraction | Exosome |
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Ref Sequence ID | NP_001029756.1 |
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Aminoacid Length | 934 |
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Molecular Weight | 104922 |
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FASTA Sequence |
Download |
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Gene Name | MSH2 |
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Gene ID | 533115 |
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Protein Existence Status | Reviewed: Experimental evidence at transcript level |
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Secondary Information |
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Protein Function | key enzyme in DNA mismatch repair that corrects mismatched bases produced during DNA replication and other biological processes; recognizes mismatches and stimulates the downstream reactions
in mismatch repair; |
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Biochemical Properties | MutS homolog 2 (MSH2) is an obligate subunit of mismatch recognition proteins MutSα (MSH2-MSH6) and MutSβ (MSH2-MSH3). |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
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Predicted Disorder Regions | 1-12,856-933 |
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DisProt Annotation | |
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TM Helix Prediction | No TM helices |
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Additional Comments | Precise regulation of MSH2 is critical, as either over- or underexpression of MSH2 results in an increased mutation frequency. |
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Bibliography | 1. Eisen, J. A. and Hanawalt, P. C. (1999) ‘A phylogenomic study of DNA repair genes, proteins, and processes.’, Mutation research, 435(3), pp. 171–213. doi: 10.1016/s0921-8777(99)00050-6. 2.Wu Q, Huang Y, Gu L, Chang Z, Li GM. OTUB1 stabilizes mismatch repair protein MSH2 by blocking ubiquitination. J Biol Chem. 2021 Jan-Jun;296:100466. doi: 10.1016/j.jbc.2021.100466. Epub 2021 Feb 26. PMID: 33640455; PMCID: PMC8042173. |