Search by BoMiProt ID - Bomi305


Primary Information

BoMiProt ID Bomi305
Protein Name DNA mismatch repair protein Msh2
Organism Bos taurus
Uniprot IDQ3MHE4
Milk FractionExosome
Ref Sequence ID NP_001029756.1
Aminoacid Length 934
Molecular Weight 104922
FASTA Sequence Download
Gene Name MSH2
Gene ID 533115
Protein Existence Status Reviewed: Experimental evidence at transcript level

Secondary Information

Protein Function key enzyme in DNA mismatch repair that corrects mismatched bases produced during DNA replication and other biological processes; recognizes mismatches and stimulates the downstream reactions in mismatch repair;
Biochemical Properties  MutS homolog 2 (MSH2) is an obligate subunit of mismatch recognition proteins MutSα (MSH2-MSH6) and MutSβ (MSH2-MSH3). 
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
Predicted Disorder Regions 1-12,856-933
DisProt Annotation
TM Helix Prediction No TM helices
Additional Comments Precise regulation of MSH2 is critical, as either over- or underexpression of MSH2 results in an increased mutation frequency. 
Bibliography 1. Eisen, J. A. and Hanawalt, P. C. (1999) ‘A phylogenomic study of DNA repair genes, proteins, and processes.’, Mutation research, 435(3), pp. 171–213. doi: 10.1016/s0921-8777(99)00050-6. 2.Wu Q, Huang Y, Gu L, Chang Z, Li GM. OTUB1 stabilizes mismatch repair protein MSH2 by blocking ubiquitination. J Biol Chem. 2021 Jan-Jun;296:100466. doi: 10.1016/j.jbc.2021.100466. Epub 2021 Feb 26. PMID: 33640455; PMCID: PMC8042173.