Search by BoMiProt ID - Bomi299


Primary Information

BoMiProt ID Bomi299
Protein Name Casein kinase I isoform gamma-1
Organism Bos taurus
Uniprot IdA7E3X2
Milk FractionExosome
Ref Sequence Id NP_001033235.1
Amino Acid Lenth 457
Molecular Weight 52620
Fasta Sequence https://www.uniprot.org/uniprot/A7E3X2.fasta
Gene Name CSNK1G1
Gene Id 527889
Protein Existence Status Reviewed: Experimental evidence at transcript level

Secondry Information

Presence in other biological fluids/tissue/cells golgi fractions of liver, spleen, kidney and brain
Protein Function phosphorylates caseins which is important to allow them to bind Ca2+ and for the subsequent formation of casein micelles, which remain stable in milk
Biochemical Properties cytosolic enzymes; the specific activities of casein kinase are 1433 and 30.6 pmoles/min per mg of protein in Golgi and milk respectively, giving a ratio of 47.7:1; activity inhibited by Mn2+
Significance in milk Phosphorylates any non-phosphorylated casein that is secreted and stored within the lumen of mammary alveoli
Bibliography 1. Duncan, J. S., Wilkinson, M. C. and Burgoyne, R. D. (2000) ‘Purification of Golgi casein kinase from bovine milk.’, The Biochemical journal, 350 Pt 2, pp. 463–8. Available at: http://www.ncbi.nlm.nih.gov/pubmed/10947960 (Accessed: 4 October 2019).