Primary Information |
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| BoMiProt ID | Bomi296 |
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| Protein Name | Adenylate kinase isoenzyme 1 |
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| Organism | Bos taurus |
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| Uniprot ID | P00570 |
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| Milk Fraction | Exosome |
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| Ref Sequence ID | NP_001013600.1 |
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| Aminoacid Length | 194 |
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| Molecular Weight | 21664 |
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| FASTA Sequence |
Download |
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| Gene Name | AK1 |
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| Gene ID | 280715 |
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| Protein Existence Status | Reviewed: Experimental evidence at protein level |
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Secondary Information |
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| Protein Function | catalysis of the transfer of the phosphate group
of ATP or other nucleotides to specific substrates without loss of the so
called high energy phosphate bond |
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| Biochemical Properties | loses its activity in low concentration but is stabilized by protein at a concentration of
about 1 mg. per ml. or higher; the activity was found to be greater if
the enzyme is first treated with cysteine; enzyme probably contains free -SH groups which are
readily oxidized |
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| Significance in milk | Bitter blocker in milk - Calcium compounds in breast milk are usually bitter which is blocked by adenylate cyclase |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Bibliography | 1. NODA, L., & KUBY, S. A. (1957). Adenosine triphosphate-adenosine monophosphate transphosphorylase (myokinase). I. Isolation of the crystalline enzyme from rabbit skeletal muscle. The Journal of Biological Chemistry, 226(1), 541–549. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/13428784. |
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