Search by BoMiProt ID - Bomi295

Primary Information

BoMiProt ID Bomi295
Protein Name Ubiquitin-like protein ISG15
Organism Bos taurus
Uniprot IdO02741
Milk FractionMFGM
Ref Sequence Id NP_776791.1
Amino Acid Lenth 154
Molecular Weight 17310
Fasta Sequence
Gene Name ISG15
Gene Id 281871
Protein Existence Status Reviewed: Experimental evidence at transcript level

Secondry Information

Protein Function Interferon-induced protein; covalently ligated to intracellular proteins in a parallel enzymatic reaction; target distinct subsets of intracellular proteins; participates in a number of fundamental regulatory processes through a unique posttranslational modification in which the carboxyl terminus of the polypeptide is covalently ligated to primary amines on a variety of intracellular proteins; participates in degradative targeting
PTMs UCRP is synthesized as precursors that undergo co- or posttranslational processing to yield identical carboxyl-terminal sequences of Leu-Arg-Leu-Arg-Gly-Gly
Significance of PTMs hexapeptide sequence is functionally significant, since it is the site of isopeptide bond formation to ubiquitin contributes to interactions with several ubiquitin-specific proteins such as the carboxyl-terminal hydrolases and other enzymes required for target protein conjugation
Bibliography 1. Loeb, K. R. and Haas, A. L. (1994) ‘Conjugates of ubiquitin cross-reactive protein distribute in a cytoskeletal pattern.’, Molecular and cellular biology, 14(12), pp. 8408–19. doi: 10.1128/mcb.14.12.8408.