Primary Information |
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BoMiProt ID | Bomi2921 |
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Protein Name | Plastin-3 |
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Organism | Bos taurus |
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Uniprot ID | A7E3Q8 |
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Milk Fraction | Whey |
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Aminoacid Length | 630 |
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Molecular Weight | 70798 |
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FASTA Sequence |
Download |
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Gene Name | PLS3 |
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Gene ID | 505687 |
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Protein Existence Status | Reveiwed:Experimental evidence at transcript level |
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Secondary Information |
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Protein Function | PLS3 (plastin 3, also known as T-plastin or fimbrin) has been considered a rather inconspicuous protein, involved in F-actin-binding and -bundling. |
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Biochemical Properties | PLS3 consists of 630 amino acids and the molecular mass of the protein is 70.8 kDa. In humans, the homology between PLS1 and PLS2 is 73%, 75% between PLS1 and PLS3, and 79% between PLS2 and PLS3. Comparisons of the plastin isoforms between humans and mice show 94% identity for PLS1, 96% for PLS2, and 99% for PLS3 |
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PTMs | N-acetylation at Methionine,Phosohorylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
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Predicted Disorder Regions | (1-20) |
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DisProt Annotation | |
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TM Helix Prediction | No TM helices |
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Additional Comments | when PLS3 is upregulated, it acts as a highly protective SMN-independent modifier in spinal muscular atrophy (SMA). |
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Bibliography | 1.Shinomiya H. Plastin family of actin-bundling proteins: its functions in leukocytes, neurons, intestines, and cancer. Int J Cell Biol. 2012;2012:1. doi: 10.1155/2012/213492. 2.Wolff L, Strathmann EA, Müller I, Mählich D, Veltman C, Niehoff A, Wirth B. Plastin 3 in health and disease: a matter of balance. Cell Mol Life Sci. 2021 Jul;78(13):5275-5301. doi: 10.1007/s00018-021-03843-5. Epub 2021 May 23. PMID: 34023917; PMCID: PMC8257523. |