|Protein Name||Heat shock cognate 71 kDa protein|
|Milk Fraction||Whey, MFGM, Exosome|
|Ref Sequence Id||NP_776770.2|
|Amino Acid Lenth||650|
|Protein Existence Status||Reviewed: Experimental evidence at protein level|
|Protein Function||Constitutively expressed Hsp70 family members are known as heat-shock cognate (Hsc) proteins; bind ATP; molecular chaperone normal unstressed cells; role in modifying antigen presentation; glial-axon transfer proteins; interact directly with fatty acids - interaction may be part of their mode of binding to cell membranes; resist noxious stimuli both in vitro and in vivo; ubiquitous expression of hsp70, hsp90, calreticulin and gp96 in cells essentially ensures that the MHC I presentation pathway remains functional in all nucleated cells; Hsp70 and hsp90 form heteromultimeric complexes in the cytosol with other co-chaperones; Hsp90 and hsp70 are intimately involved in the extrusion of antigens from the endosomes to the cytosol through a putative pore structure;protection of human monocytes from hydrogen peroxideinduced toxicity; guinea pig gastric mucosal cells from ethanol damage|
|Biochemical Properties||b-sheet structures are the most hydrophobic parts of HSC-70 and thus are likely to be involved in the binding of hydrophobic peptides; changes in resting pHi neither affect the baseline levels of HSP-70 nor alter the ability of heat shock to induce HSP-70 as found in human A-431 cells;|
|Significance in milk||heat stress proteins in mamary gland|
|Significance of PTMs||sensitive to heat stress and mainly responsible for mammary cell protection from heat stress|
|PDB ID||1ATR, 1ATS, 1BA0, 1BA1, 1BUP, 1HPM, 1HX1, 1KAX, 1KAY, 1KAZ, 1NGA, 1NGB, 1NGC, 1NGD, 1NGE, 1NGF, 1NGG, 1NGH, 1NGI, 1NGJ, 1Q2G, 1QQM, 1QQN, 1QQO, 1YUW, 2BUP, 2QW9, 2QWL, 2QWM, 2QWN, 2QWO, 2QWP, 2QWQ, 2QWR, 3C7N, 3HSC, 4FL9,|
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