|Protein Name||Heat shock protein 105 kDa|
|Milk Fraction||MFGM, Exosome|
|Ref Sequence Id||NP_001068770.1|
|Protein Existence Status||Reviewed: Experimental evidence at transcript level|
|Presence in other biological fluids/tissue/cells||105-kDa heat-shock protein (HSP105) as a mammalian high molecular mass heat-shock protein in human, mouse, and rat cells; moderately expressed in adrenal, spleen, liver, lung, and heart; Small amounts of HSP105 are expressed in the kidney, stomach, muscle, testis, and lens. However, in brain HSP105-a was characteristically highly expressed over HSP105-b|
|Protein Function||induced in various tissues of rat after whole-body hyperthermia; HSP105 level of HSP10S increased markedly in the embryos from gestational day (GD) 9 to 11, then decreased gradually by GD 14; plays important roles in mouse embryogenesis; prevent the aggregation of heat-denatured proteins in vitro;|
|Biochemical Properties||HSPI05 is composed of two isoforms with slightly different isoelectric points with slightly different isoelectric points, acidic and basic isoforms; mRNA was also induced by azetidine-2-carboxylic acid, sodium arsenite, zinc sulfate, and cupric sulfate;|
|Significance in milk||heat stress proteins in mamary gland|
| Site(s) of PTM(s) |
|Predicted Disorder Regions||515-585,797-859|
|TM Helix Prediction||No TM helices|
|Significance of PTMs||sensitive to heat stress and mainly responsible for mammary cell protection from heat stress|
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