Primary Information |
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BoMiProt ID | Bomi289 |
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Protein Name | Solute carrier family 2, facilitated glucose transporter member 1 |
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Organism | Bos taurus |
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Uniprot ID | P27674 |
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Milk Fraction | Exosome |
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Ref Sequence ID | NP_777027.1 |
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Aminoacid Length | 492 |
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Molecular Weight | 54132 |
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FASTA Sequence |
Download |
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Gene Name | SLC2A1 |
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Gene ID | 282356 |
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Protein Existence Status | Reviewed: Experimental evidence at protein level |
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Secondary Information |
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Presence in other biological fluids/tissue/cells | widely distributed
and are present on the surface of probably all
mammalian cells; highest levels are in placenta, brain, and kidney |
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Protein Function | catalyses facilitative diffusion of glucose into erythrocytes and is responsible for glucose
supply to the brain and other organs; mediates the basal-level cellular uptake
of glucose into many tissues; functionally important
either for transport of glucose or for the regulation
of transport activity |
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Biochemical Properties | belongs to the sugar porter subfamily of the major facilitator
superfamily; comprises 12 transmembrane segments organized into two discretely
folded domains, namely the amino- and carboxy-terminaldomains; extracellular
loop of 33 amino acids connects transmembrane
segments M1 and M2 |
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Significance in milk | nutrient transport systems for milk precursors and constituents |
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PTMs | Glycosylated: M1 and M2 and contains a potential site for asparagine-linked gloycosylation (Asn-Xaa-
Thr/Ser; Fig. 2) |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
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Predicted Disorder Regions | 1-8,241-251,471-492 |
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DisProt Annotation | |
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TM Helix Prediction | 12TMHs; (13-35),(65-87),(94-112),(121-143),(154-176),(185-207),(272-294),(306-328),(335-357),(369-391),(402-424),(428-450) |
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Bibliography | 1. Deng, D. et al. (2014) ‘Crystal structure of the human glucose transporter GLUT1’, Nature, 510(7503), pp. 121–125. doi: 10.1038/nature13306. 2. Mueckler, M. et al. (1985) ‘Sequence and structure of a human glucose transporter’, Science, 229(4717), pp. 941–945. doi: 10.1126/science.3839598. 3. Thorens, B. et al. (1988) ‘Cloning and functional expression in bacteria of a novel glucose transporter present in liver, intestine, kidney, and β-pancreatic islet cells’, Cell, 55(2), pp. 281–290. doi: 10.1016/0092-8674(88)90051-7. |