Primary Information |
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| BoMiProt ID | Bomi2850 |
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| Protein Name | Neural Wiskott-Aldrich syndrome protein |
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| Organism | Bos taurus |
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| Uniprot ID | Q95107 |
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| Milk Fraction | Exosome |
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| Ref Sequence ID | NP_776644.1 |
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| Aminoacid Length | 505 |
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| Molecular Weight | 54672 |
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| FASTA Sequence |
Download |
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| Gene Name | WASL |
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| Gene ID | 281577 |
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| Protein Existence Status | Reviewed: Experimental evidence at protein level |
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Secondary Information |
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| Protein Function | Wiskott-Aldrich syndrome family proteins act downstream of these GTPases, controlling actin assembly and cytoskeletal reorganization. |
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| PTMs | Omega-N-methylation at Arginine,Phosphorylation at Ser-242,484,485 and Tyr-256,N-acetylation at Serine |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
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| Predicted Disorder Regions | 138-163,185-205,266-406,449-468,477-501 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Significance of PTMs | Phosphorylation at Ser and Tyr, enhances actin polymerization activity. |
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| Additional Comments | N-WASP deficiency also led to abnormal proliferation of skin progenitor cells, resulting in their depletion over time. |
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| Bibliography | Lyubimova A, Garber JJ, Upadhyay G, Sharov A, Anastasoaie F, Yajnik V, Cotsarelis G, Dotto GP, Botchkarev V, Snapper SB. Neural Wiskott-Aldrich syndrome protein modulates Wnt signaling and is required for hair follicle cycling in mice. J Clin Invest. 2010 Feb;120(2):446-56. doi: 10.1172/JCI36478. Epub 2010 Jan 11. PMID: 20071778; PMCID: PMC2810069. |
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