Primary Information |
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BoMiProt ID | Bomi2801 |
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Protein Name | Transportin-1 |
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Organism | Bos taurus |
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Uniprot ID | Q3SYU7 |
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Milk Fraction | Exosome |
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Ref Sequence ID | NP_001070008.1 |
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Aminoacid Length | 898 |
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Molecular Weight | 102383 |
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FASTA Sequence |
Download |
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Gene Name | TNPO1 |
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Gene ID | 767620 |
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Protein Existence Status | Reveiwed:Experimental evidence at protein level |
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Secondary Information |
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Protein Function | Transportin-1 (Trn1), also known as karyopherin-β2 (Kapβ2), is probably the best-characterized nuclear import receptor of the karyopherin-β family after Importin-β |
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Biochemical Properties | Trn1 shows only 24% sequence similarity to Importin-β.They share a higher similarity at the level of their N-terminal half where the binding of RanGTP takes place, and differ deeply at the level of their C-terminal half, the site of binding to their respective cargoes. Whereas Importin-β binds via the adaptor protein Importin-α to cargoes harbouring the ‘classical’ NLS (cNLS), Trn1 binds directly to its cargoes without adaptor |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
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Predicted Disorder Regions | 9-37,45-54,167-178,319-379 |
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DisProt Annotation | |
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TM Helix Prediction | No TM helices |
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Bibliography | 1.Mboukou A, Rajendra V, Kleinova R, Tisné C, Jantsch MF, Barraud P. Transportin-1: A Nuclear Import Receptor with Moonlighting Functions. Front Mol Biosci. 2021 Feb 18;8:638149. doi: 10.3389/fmolb.2021.638149. PMID: 33681296; PMCID: PMC7930572. 2.Structure of importin-beta bound to the IBB domain of importin-alpha.Cingolani G, Petosa C, Weis K, Müller CW.Nature. 1999 May 20; 399(6733):221-9. 3.Structure of the nuclear transport complex karyopherin-beta2-Ran x GppNHp.Chook YM, Blobel G.Nature. 1999 May 20; 399(6733):230-7. 4.Nuclear import by karyopherin-βs: recognition and inhibition.Chook YM, Süel KE.Biochim Biophys Acta. 2011 Sep; 1813(9):1593-606. 5.Structural biology of nucleocytoplasmic transport.Cook A, Bono F, Jinek M, Conti E.Annu Rev Biochem. 2007; 76():647-71. 6.Transportin-1 and Transportin-2: protein nuclear import and beyond.Twyffels L, Gueydan C, Kruys V.FEBS Lett. 2014 May 21; 588(10):1857-68. |