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Primary Information | |
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| BoMiProt ID | Bomi2763 |
| Protein Name | Supervillin |
| Organism | Bos taurus |
| Uniprot ID | O46385 |
| Milk Fraction | Exosome |
| Ref Sequence ID | NP_776615.1 |
| Aminoacid Length | 2194 |
| Molecular Weight | 244892 |
| FASTA Sequence | Download |
| Gene Name | SVIL |
| Gene ID | 281509 |
| Protein Existence Status | Reveiwed:Experimental evidence at protein level |
Secondary Information | |
| Protein Function | Supervillin (SVIL) is an actin-binding and membrane-associated protein, which belongs to villin/gelsolin family.SVIL is involved in the regulation of macrophages' movement and lipopolysaccharide (LPS) increased the SVIL mRNA expression in neutrophils. |
| PTMs | Phosphorylation at Ser/Thr/Tyr |
| Linking IDs | Bomi2763 |
| Bibliography | Zhou J, Que Y, Pan L, Li X, Zhu C, Jin L, Li S. Supervillin Contributes to LPS-induced Inflammatory Response in THP-1 Cell-derived Macrophages. Inflammation. 2022 Feb;45(1):356-371. doi: 10.1007/s10753-021-01551-7. Epub 2021 Sep 3. PMID: 34480249. |
| Protein Function | Supervillin (SVIL) is an actin-binding and membrane-associated protein, which belongs to villin/gelsolin family.SVIL is involved in the regulation of macrophages' movement and lipopolysaccharide (LPS) increased the SVIL mRNA expression in neutrophils. |
| PTMs | Phosphorylation at Ser/Thr/Tyr |
| Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation | |
| Predicted Disorder Regions | NA |
| DisProt Annotation | Disorder content 15.6% Term protein binding, Fragment 11 - 174 Term molecular adaptor activity, Fragment 1 - 342 |
| TM Helix Prediction | No TM helices |
| Linking IDs | |
| Bibliography | Zhou J, Que Y, Pan L, Li X, Zhu C, Jin L, Li S. Supervillin Contributes to LPS-induced Inflammatory Response in THP-1 Cell-derived Macrophages. Inflammation. 2022 Feb;45(1):356-371. doi: 10.1007/s10753-021-01551-7. Epub 2021 Sep 3. PMID: 34480249. |