Primary Information | |
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BoMiProt ID | Bomi2756 |
Protein Name | Serine/arginine-rich splicing factor 7 |
Organism | Bos taurus |
Uniprot ID | Q3T106 |
Milk Fraction | MFGM |
Ref Sequence ID | NP_001029449.1 |
Aminoacid Length | 235 |
Molecular Weight | 26941 |
FASTA Sequence | Download |
Gene Name | SRSF7 |
Gene ID | 507066 |
Protein Existence Status | Reveiwed:Experimental evidence at transcript level |
Secondary Information | |
Protein Function | Plays an important role in constitutive and alternative splicing as well as during several steps of RNA metabolism; known to promote cross-intron and cross-exon interactions; interact with exonic splicing enhancers and stimulate the splicing of adjacent introns |
Biochemical Properties | Properties are characteristic of intrinsically disordered (ID) proteins; RS domains are completely unstructured; prevalence of hydrophilic and charged amino acids and lesser hydrophobic and aromatic amino acids amongst the disordered regions; slightly enriched in tyrosin residue- presence of partial hydrophobicity, aromatic side chain and a reactive hydroxyl group might participate in stacking interactions with the RNA bases; depletion of SR proteins in the negatively charged D and E and their enrichment in the positively charged K and R may be essential for interaction with the negatively charged RNA |
PTMs | RS domains of SR proteins are extensively phosphorylated by two families of kinases, the SR protein-specific kinases (SRPKs) and Clk/Sty protein kinases; methylation and ubiquitination are also predicted to occur in disordered protein regions |
Significance of PTMs | Phosphorylation is required for translocation of SR proteins from the cytoplasm to the nucleus, and it is also known to regulate the activity of SR proteins during early development |
Linking IDs | Bomi83 |
Bibliography | 1. Haynes, C., & Iakoucheva, L. M. (2006). Serine/arginine-rich splicing factors belong to a class of intrinsically disordered proteins. Nucleic Acids Research, 34(1), 305–312. https://doi.org/10.1093/nar/gkj424 |
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation | |
Predicted Disorder Regions | (123-235) |
DisProt Annotation | |
TM Helix Prediction | No TM helices |