Primary Information |
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| BoMiProt ID | Bomi2735 |
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| Protein Name | Endophilin-A2 |
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| Organism | Bos taurus |
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| Uniprot ID | Q2KJA1 |
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| Milk Fraction | Exosome |
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| Ref Sequence ID | NP_001039595.1 |
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| Aminoacid Length | 368 |
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| Molecular Weight | 41455 |
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| FASTA Sequence |
Download |
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| Gene Name | SH3GL1 |
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| Gene ID | 512719 |
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| Protein Existence Status | Reviewed: Experimental evidence at transcript level |
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Secondary Information |
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| Protein Function | The requirement for endophilin A2 highlights a unique importance of clathrin-independent intracellular trafficking in GC B-cell clonal expansion and antibody responses. |
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| PTMs | Phosphorylation at Ser/Thr |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
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| Predicted Disorder Regions | (243-308) |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Additional Comments | Overexpression of endophilin A2 does not affect the TMEM16A mRNA level, but markedly decreases TMEM16A protein level in BASMCs by inducing ubiquitination and autophagy of TMEM16A. |
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| Bibliography | 1.Liu CZ, Li FY, Lv XF, Ma MM, Li XY, Lin CX, Wang GL, Guan YY. Endophilin A2 regulates calcium-activated chloride channel activity via selective autophagy-mediated TMEM16A degradation. Acta Pharmacol Sin. 2020 Feb;41(2):208-217. doi: 10.1038/s41401-019-0298-5. Epub 2019 Sep 4. PMID: 31484993; PMCID: PMC7470808. |
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