|
|
|
Primary Information | |
|---|---|
| BoMiProt ID | Bomi2733 |
| Protein Name | Septin-8 |
| Organism | Bos taurus |
| Uniprot ID | Q0VCP4 |
| Milk Fraction | Exosome |
| Ref Sequence ID | NP_001069698.1 |
| Aminoacid Length | 442 |
| Molecular Weight | 51250 |
| FASTA Sequence | Download |
| Gene Name | SEPTIN8 |
| Gene ID | 540614 |
| Protein Existence Status | Reveiwed:Experimental evidence at transcript level |
Secondary Information | |
| Protein Function | Septin filaments have a potential to form higher-order structures by self-organization; septin-based ring is necessary as the structural basis for cell wall deposition above the bud neck membrane; mammalian septins and related proteins are also implicated in exocytosis , apoptosis, leukemogenesis and carcinogenesis and neurodegeneration |
| Biochemical Properties | Eukaryotic subfamily of guanine nucleotide binding proteins which form filamentous heteropolymer complexes; Septin filaments can assemble into bundles either autonomously or depending on actin bundles, using them as templates or scaffolds |
| Linking IDs | Bomi81 |
| Bibliography | 1. Hsu, S. C., Hazuka, C. D., Roth, R., Foletti, D. L., Heuser, J., & Scheller, R. H. (1998). Subunit composition, protein interactions, and structures of the mammalian brain sec6/8 complex and septin filaments. Neuron, 20(6), 1111–1122. https://doi.org/10.1016/s0896-6273(00)80493-6. 2. Kinoshita, A., Kinoshita, M., Akiyama, H., Tomimoto, H., Akiguchi, I., Kumar, S., … Kimura, J. (1998). Identification of septins in neurofibrillary tangles in Alzheimer’s disease. The American Journal of Pathology, 153(5), 1551–1560. https://doi.org/10.1016/S0002-9440(10)65743-4. 3. DeMarini, D. J., Adams, A. E., Fares, H., De Virgilio, C., Valle, G., Chuang, J. S., & Pringle, J. R. (1997). A septin-based hierarchy of proteins required for localized deposition of chitin in the Saccharomyces cerevisiae cell wall. The Journal of Cell Biology, 139(1), 75–93. https://doi.org/10.1083/jcb.139.1.75. |
| Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation | |
| Predicted Disorder Regions | 1-22,379-442 |
| DisProt Annotation | |
| TM Helix Prediction | No TM helices |