Search by BoMiProt ID - Bomi273

Primary Information

BoMiProt ID Bomi273
Protein Name Aspartyl aminopeptidase
Organism Bos taurus
Uniprot IdQ2HJH1
Milk FractionExosome
Ref Sequence Id NP_001039417.1
Amino Acid Lenth 471
Molecular Weight 51828
Fasta Sequence
Gene Name DNPEP
Gene Id 506882
Protein Existence Status Reviewed: Experimental evidence at protein level

Secondry Information

Presence in other biological fluids/tissue/cells kidney, lung, and immune cells; expressed in many organ systems with especially high activity in the brain and testis
Protein Function play an essential role in cellular metabolism that has remained conserved throughout evolution; regulation of the renin-angiotensin system
Biochemical Properties acidic residue specific aminopeptidases; belongs to the M18 metallopeptidase family; is a self-compartmentalized, binuclear zinc-containing enzyme that forms a tetrahedron-shaped homododecameric complex; cytosolic, although it also exists in a membrane-associated form in some tissues; inhibitors - Nonselective metal chelators, reducing agents, and a substrate analog, aspartic acid hydroxamate
Bibliography 1. Chen, Y. et al. (2014) ‘Identification and Characterization of Novel Inhibitors of Mammalian Aspartyl Aminopeptidase’, Molecular Pharmacology, 86(2), pp. 231–242. doi: 10.1124/mol.114.093070.