Search by BoMiProt ID - Bomi273


Primary Information

BoMiProt ID Bomi273
Protein Name Aspartyl aminopeptidase
Organism Bos taurus
Uniprot IdQ2HJH1
Milk FractionExosome
Ref Sequence Id NP_001039417.1
Amino Acid Lenth 471
Molecular Weight 51828
Fasta Sequence https://www.uniprot.org/uniprot/Q2HJH1.fasta
Gene Name DNPEP
Gene Id 506882
Protein Existence Status Reviewed: Experimental evidence at protein level

Secondry Information

Presence in other biological fluids/tissue/cells kidney, lung, and immune cells; expressed in many organ systems with especially high activity in the brain and testis
Protein Function play an essential role in cellular metabolism that has remained conserved throughout evolution; regulation of the renin-angiotensin system
Biochemical Properties acidic residue specific aminopeptidases; belongs to the M18 metallopeptidase family; is a self-compartmentalized, binuclear zinc-containing enzyme that forms a tetrahedron-shaped homododecameric complex; cytosolic, although it also exists in a membrane-associated form in some tissues; inhibitors - Nonselective metal chelators, reducing agents, and a substrate analog, aspartic acid hydroxamate
PDB ID 3VAR, 3VAT,
Bibliography 1. Chen, Y. et al. (2014) ‘Identification and Characterization of Novel Inhibitors of Mammalian Aspartyl Aminopeptidase’, Molecular Pharmacology, 86(2), pp. 231–242. doi: 10.1124/mol.114.093070.