Primary Information |
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| BoMiProt ID | Bomi270 |
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| Protein Name | Beta Defensin 10 |
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| Organism | Bos taurus |
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| Uniprot ID | P46168 |
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| Milk Fraction | MFGM |
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| Ref Sequence ID | NP_001108556.1 |
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| Aminoacid Length | 62 |
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| Molecular Weight | 6928 |
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| FASTA Sequence |
Download |
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| Gene Name | DEFB10 |
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| Gene ID | 100141457 |
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| Protein Existence Status | Reviewed: Experimental evidence at protein level |
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Secondary Information |
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| Protein Function | amphipathic cationic peptides that
have been reported to function as AMPs for the Gramnegative,
Gram-positive bacteria, viruses, fungi, and
other unicellular parasites; confer resistance against
mastitis in cattle and buffalo next to the TLRs; |
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| Biochemical Properties | cationic and cysteine-rich
AMP displaying a varied pattern of cysteine spacing and
disulfide bonding between cysteine residues; |
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| Significance in milk | higher in early lactation stages than in the later stages
on infection by coagulase-positive Staphylococci |
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| PTMs | Disulfide bond formation and Pyrrolidone carboxylic acid attachment |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
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| Predicted Disorder Regions | 54-58,61-62 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Bibliography | 1. Birchler, T. et al. (2001) ‘Human Toll-like receptor 2 mediates induction of the antimicrobial peptide human beta-defensin 2 in response to bacterial lipoprotein.’, European journal of immunology, 31(11), pp. 3131–7. doi: 10.1002/1521-4141(200111)31:11<3131::AID-IMMU3131gt;3.0.CO;2-G. |
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