Primary Information |
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| BoMiProt ID | Bomi2679 |
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| Protein Name | Receptor expression-enhancing protein 5 |
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| Organism | Bos taurus |
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| Uniprot ID | Q29RM3 |
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| Milk Fraction | MFGM, Exosome |
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| Ref Sequence ID | NP_001040070.1 |
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| Aminoacid Length | 189 |
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| Molecular Weight | 21417 |
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| FASTA Sequence |
Download |
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| Gene Name | REEP5 |
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| Gene ID | 617543 |
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| Protein Existence Status | Reviewed: Experimental evidence at transcript level |
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Secondary Information |
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| Protein Function | A cardiac enriched SR/ER membrane protein REEP5 that is centrally involved in regulating SR/ER organization and cellular stress responses in cardiac myocytes. |
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| Biochemical Properties | REEP5 in cardiac myocytes showed localization of REEP5 to different functional domains of the SR/ER network in the myocyte including the tubular/longitudinal SR/ER network where protein synthesis, trafficking, and modification takes place.REEP5 interactions with several members of the reticulon (RTN) and atlastin (ATL) families of proteins, as well as cytoskeleton associated protein 4 (CKAP4). These interacting proteins have been linked previously to ER membrane-shaping functions including high curvature formation, tubule fusion, and intraluminal spacing. |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | 2TMHs; (35-57), (88-110) |
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| Bibliography | 1.Lee SH, Hadipour-Lakmehsari S, Gramolini AO. Towards understanding the role of Receptor Expression Enhancing Protein 5 (REEP5) in cardiac muscle and beyond. Cell Stress. 2020 Apr 15;4(6):151-153. doi: 10.15698/cst2020.06.223. PMID: 32548572; PMCID: PMC7278519. |
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