Primary Information |
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| BoMiProt ID | Bomi2677 |
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| Protein Name | Histone-binding protein RBBP4 |
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| Organism | Bos taurus |
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| Uniprot ID | Q3MHL3 |
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| Milk Fraction | MFGM, Exosome |
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| Ref Sequence ID | NP_001070481.1 |
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| Aminoacid Length | 425 |
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| Molecular Weight | 47656 |
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| FASTA Sequence |
Download |
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| Gene Name | RBBP4 |
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| Gene ID | 767940 |
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| Protein Existence Status | Reviewed: Experimental evidence at protein level |
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Secondary Information |
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| Protein Function | RbAp48, a histone-binding protein that modifies histone acetylation. RbAp48/Rbbp4 is a molecular determinant of Age-Related Memory Loss. |
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| PTMs | N-acetylalanine,Isopeptide bond formation,Phosphorylation at Ser,Ubl conjugation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
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| Predicted Disorder Regions | 1-24,89-113,352-362,411-425 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Additional Comments | Inhibition of RbAp48 in the hippocampal formation inhibits OCN's beneficial functions in cognition and causes deficits in discrimination memory. |
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| Bibliography | 1.Kosmidis S, Polyzos A, Harvey L, Youssef M, Denny CA, Dranovsky A, Kandel ER. RbAp48 Protein Is a Critical Component of GPR158/OCN Signaling and Ameliorates Age-Related Memory Loss. Cell Rep. 2018 Oct 23;25(4):959-973.e6. doi: 10.1016/j.celrep.2018.09.077. PMID: 30355501; PMCID: PMC7725275. 2.Pavlopoulos E, Jones S, Kosmidis S, Close M, Kim C, Kovalerchik O, Small SA, Kandel ER. Molecular mechanism for age-related memory loss: the histone-binding protein RbAp48. Sci Transl Med. 2013 Aug 28;5(200):200ra115. doi: 10.1126/scitranslmed.3006373. PMID: 23986399; PMCID: PMC4940031. |
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