Primary Information |
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BoMiProt ID | Bomi2671 |
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Protein Name | DNA repair protein RAD51 homolog 1 |
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Organism | Bos taurus |
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Uniprot ID | Q2KJ94 |
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Milk Fraction | Exosome |
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Ref Sequence ID | NP_001039644.1 |
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Aminoacid Length | 339 |
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Molecular Weight | 36982 |
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FASTA Sequence |
Download |
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Gene Name | RAD51 |
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Gene ID | 514749 |
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Protein Existence Status | Reviewed: Experimental evidence at transcript level |
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Secondary Information |
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Protein Function | RAD51 is required for proper porcine parthenogenetic activation (PA) embryo development. |
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PTMs | N-acetylation at Alanine,Phosphorylation at Tyrosine,Ubiquitination |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
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Predicted Disorder Regions | 1-20,86-114,268-292 |
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DisProt Annotation | |
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TM Helix Prediction | No TM helices |
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Significance of PTMs | Ubiquitinated by the SCF(FBH1) E3 ubiquitin ligase complex, regulating RAD51 subcellular location and preventing its association with DNA. Ubiquitinated by RFWD3 in response to DNA damage: ubiquitination leads to degradation by the proteasome, promoting homologous recombination. Phosphorylation of Thr-309 by CHEK1 may enhance association with chromatin at sites of DNA damage and promote DNA repair by homologous recombination. Phosphorylation by ABL1 inhibits function. |
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Bibliography | 1.Jin ZL, Shen XH, Shuang L, Kwon JW, Seong MJ, Kim NH. Inhibition of DNA repair protein RAD51 affects porcine preimplantation embryo development. Reproduction. 2019 Mar 1;157(3):223-234. doi: 10.1530/REP-18-0271. PMID: 30817312. |