Primary Information |
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| BoMiProt ID | Bomi2670 |
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| Protein Name | Rab GTPase-binding effector protein 2 |
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| Organism | Bos taurus |
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| Uniprot ID | A4FUG8 |
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| Milk Fraction | Exosome |
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| Ref Sequence ID | NP_001076877.2 |
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| Aminoacid Length | 585 |
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| Molecular Weight | 65602 |
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| FASTA Sequence |
Download |
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| Gene Name | RABEP2 |
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| Gene ID | 511736 |
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| Protein Existence Status | Reviewed: Experimental evidence at transcript level |
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Secondary Information |
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| Protein Function | Rab-GTPase binding effector protein 2 (RABEP2) is identified as a novel GSK3 substrate and GSK3 phosphorylation of RABEP2 at Ser200 was enhanced by prior phosphorylation at Ser204, fitting the known consensus sequence for GSK3 substrates. |
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| Biochemical Properties | RABEP2 has 42% sequence homology with rabaptin-5 (RABEP1) and is predicted to contain a C-terminal Rab5-binding domain plus an N-terminal Rabex-5-binding domain. |
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| PTMs | N-acetylation at Alanine,Phosphorylation at Serine |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
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| Predicted Disorder Regions | 178-265, 381-408, 491-515 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Bibliography | 1.Logie L, Van Aalten L, Knebel A, Force T, Hastie CJ, MacLauchlan H, Campbell DG, Gourlay R, Prescott A, Davidson J, Fuller W, Sutherland C. Rab-GTPase binding effector protein 2 (RABEP2) is a primed substrate for Glycogen Synthase kinase-3 (GSK3). Sci Rep. 2017 Dec 15;7(1):17682. doi: 10.1038/s41598-017-17087-6. PMID: 29247183; PMCID: PMC5732219. |
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