Primary Information |
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BoMiProt ID | Bomi2631 |
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Protein Name | 3'-phosphoadenosine 5'-phosphosulfate synthase 1 |
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Organism | Bos taurus |
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Uniprot ID | Q3T0J0 |
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Milk Fraction | Exosome |
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Ref Sequence ID | NP_001029382.1 |
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Aminoacid Length | 624 |
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Molecular Weight | 70954 |
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FASTA Sequence |
Download |
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Gene Name | PAPSS1 |
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Gene ID | 504439 |
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Protein Existence Status | unreviewed |
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Secondary Information |
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Protein Function | 3'-phosphoadenosine 5'-phosphosulfate (PAPS) synthase (PAPSS) catalyzes the biosynthesis of PAPS which serves as the universal sulfonate donor compound for all sulfotransferase reactions. |
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Biochemical Properties | In humans there are two major isoforms PAPSS1 and PAPSS2. In brain and skin PAPSS1 is the major expressed isoform, whereas in liver, cartilage and adrenal glands PAPSS2 isoform expression predominates and in various other tissues the proportions of the isoform expressions is purported to vary. The deduced amino acid sequences of the two isoforms reveal 77% identity between PAPSS1 and PAPSS2. In addition there is a splice variant PAPSS2b which contains notably an extra five amino acid sequence GMALP. |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
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Predicted Disorder Regions | NA |
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DisProt Annotation | |
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TM Helix Prediction | No TM helices |
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Bibliography | 1.Venkatachalam KV. Human 3'-phosphoadenosine 5'-phosphosulfate (PAPS) synthase: biochemistry, molecular biology and genetic deficiency. IUBMB Life. 2003 Jan;55(1):1-11. doi: 10.1080/1521654031000072148. PMID: 12716056. |