Search by BoMiProt ID - Bomi2631


Primary Information

BoMiProt ID Bomi2631
Protein Name 3'-phosphoadenosine 5'-phosphosulfate synthase 1
Organism Bos taurus
Uniprot IDQ3T0J0
Milk FractionExosome
Ref Sequence ID NP_001029382.1
Aminoacid Length 624
Molecular Weight 70954
FASTA Sequence Download
Gene Name PAPSS1
Gene ID 504439
Protein Existence Status unreviewed

Secondary Information

Protein Function 3'-phosphoadenosine 5'-phosphosulfate (PAPS) synthase (PAPSS) catalyzes the biosynthesis of PAPS which serves as the universal sulfonate donor compound for all sulfotransferase reactions.
Biochemical Properties In humans there are two major isoforms PAPSS1 and PAPSS2. In brain and skin PAPSS1 is the major expressed isoform, whereas in liver, cartilage and adrenal glands PAPSS2 isoform expression predominates and in various other tissues the proportions of the isoform expressions is purported to vary. The deduced amino acid sequences of the two isoforms reveal 77% identity between PAPSS1 and PAPSS2. In addition there is a splice variant PAPSS2b which contains notably an extra five amino acid sequence GMALP.
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Bibliography 1.Venkatachalam KV. Human 3'-phosphoadenosine 5'-phosphosulfate (PAPS) synthase: biochemistry, molecular biology and genetic deficiency. IUBMB Life. 2003 Jan;55(1):1-11. doi: 10.1080/1521654031000072148. PMID: 12716056.