Primary Information | |
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BoMiProt ID | Bomi2616 |
Protein Name | BoLA-DR-alpha |
Organism | Bos taurus |
Uniprot ID | Q30309 |
Milk Fraction | MFGM |
Ref Sequence ID | NP_001012695.1 |
Aminoacid Length | 253 |
Molecular Weight | 28407 |
FASTA Sequence | Download |
Gene Name | BoLA-DRA |
Gene ID | 506214 |
Protein Existence Status | Unreveiwed:Experimental evidence at protein level |
Secondary Information | |
Protein Function | major histocompatibility complex (MHC) of cattle is known as the bovine leukocyte antigen (BoLA) and is located on chromosome 23; linked to variation in resistance to disease including bovine leukemia virus-induced lymphoma and mastitis |
Biochemical Properties | existence of up three expressed class I loci in cattle |
Significance in milk | influence traits such as milk yield, growth and reproduction, which are not often measured in humans, and variations in individual immune response to antigen; likely to play an important role in cattle immune responses |
PTMs | Disulfide bond formation,N-Linked Glycosylation at Asn, Phosphorylation at Ser |
Linking IDs | Bomi62 |
Bibliography | 1. Weigel, K. A., Freeman, A. E., Kehrli, M. E., Stear, M. J., & Kelley, D. H. (1990). Association of class I bovine lymphocyte antigen complex alleles with health and production traits in dairy cattle. Journal of Dairy Science, 73(9), 2538–2546. https://doi.org/10.3168/jds.S0022-0302(90)78939-4. 2. Joosten, I., Teale, A. J., van der Poel, A., & Hensen, E. J. (1992). Biochemical evidence of the expression of two major histocompatibility complex class I genes on bovine peripheral blood mononuclear cells. Animal Genetics, 23(2), 113–123. https://doi.org/10.1111/j.1365-2052.1992.tb00030. 3. Joosten, I., Sanders, M. F., & Hensen, E. J. (1991). Involvement of major histocompatibility complex class I compatibility between dam and calf in the aetiology of bovine retained placenta. Animal Genetics, 22(6), 455–463. https://doi.org/10.1111/j.1365-2052.1991.tb00717. 4. al-Murrani, S. W., Glass, E. J., & Hopkins, J. (1994). BoLA class I charge heterogeneity reflects the expression of more than two loci. Animal Genetics, 25(3), 165–172. https://doi.org/10.1111/j.1365-2052.1994.tb00105. |
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation |