Search by BoMiProt ID - Bomi2599


Primary Information

BoMiProt ID Bomi2599
Protein Name Dehydrogenase/reductase (SDR family) member 1
Organism Bos taurus
Uniprot IDQ2KIS4
Milk FractionMFGM, Exosome
Ref Sequence ID NP_001039759.1
Aminoacid Length 312
Molecular Weight 34020
FASTA Sequence Download
Gene Name DHRS1
Gene ID 528832
Protein Existence Status Unreveiwed:Experimental evidence at transcript level

Secondary Information

Protein Function member of the short-chain dehydrogenase/reductase (SDR) superfamily; play an important role in various (patho)biochemical pathways including intermediary metabolism and biotransformation of xenobiotics. 3 alpha-Hydroxysteroid dehydrogenase (3 alpha HSD) is one of the main enzymes involved in the metabolism of the active androgen, dihydrotestosterone (DHT). 
Biochemical Properties integral protein of the endoplasmic reticulum,facing towards the lumen with a reducing activity toward several substrates bearing carbonyl groups, such as steroid hormones,xenobiotics and model substrates prerferably NADPH as the cofactor; mostly three transmembrane segments; hydrophobic middle and C-term predicted transmembrane segments might be part of the homodimer formation/interaction sites. 3 alpha HSD catalyzes the reversible reduction of DHT to 5 alpha-androstane-3 alpha, 17 beta-diol (3 alpha DIOL). The equilibrium of 3 alpha HSD reductive and oxidative activity is an important factor in the regulation of intracellular levels of DHT.
Significance in milk oxidoreductase enzyme in milk
PTMs No glycosylation motif
Linking IDs Bomi55
Bibliography 1. Hirokawa, T., Boon-Chieng, S., & Mitaku, S. (1998). SOSUI: classification and secondary structure prediction system for membrane proteins. Bioinformatics (Oxford, England), 14(4), 378–379. https://doi.org/10.1093/bioinformatics/14.4.378.
2. Stambergova, H., Skarydova, L., Dunford, J. E., & Wsol, V. (2014). Biochemical properties of human dehydrogenase/reductase (SDR family) member 7. Chemico-Biological Interactions, 207, 52–57. https://doi.org/10.1016/j.cbi.2013.11.003. 3.Pirog EC, Collins DC. 3 Alpha-hydroxysteroid dehydrogenase activity in rat liver and skin. Steroids. 1994 Apr;59(4):259-64. doi: 10.1016/0039-128x(94)90110-4. PMID: 8079380.
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation