Primary Information
BoMiProt ID	Bomi258
Protein Name	Cysteine and glycine-rich protein 1
Organism	Bos taurus
Uniprot ID	Q3MHY1
Milk Fraction	Exosome
Ref Sequence ID	NP_001077240.1
Aminoacid Length	193
Molecular Weight	20612
FASTA Sequence	Download
Gene Name	CSRP1
Gene ID	615329
Protein Existence Status	Reviewed: Experimental evidence at transcript level
Secondary Information
Presence in other biological fluids/tissue/cells	exhibit a tissue-specific distribution with a unique dual subcellular localization - CRP1 is detected in smooth muscle, CRP2 is restricted to arteries and fibroblasts, and CRP3 is found in organs enriched in striate muscle;
Protein Function	implicated in diverse cellular processes linked to differentiation, growth control, and pathogenesis; implicated in specific protein-protein interactions involving cytoskeletal components like zyxin, actin, and α-actinin; essential for the maintenance of normal cell function
Biochemical Properties	contain two zinc-binding specific double zinc finger domain (LIM domains), LIM1 (amino-terminal) and LIM2 (carboxyl- terminal) - linked to short glycine-rich regions; can associate with the actin cytoskeleton and are capable of interacting with α-actinin and zyxin when overexpressed in adherent fibroblasts; also interacts with the basic helix-loop-helix myogenic transcription factors MyoD, myogenin and MRF4, increasing their affinity for specific DNA regulatory elements;
PTMs	Phosphorylation at Serine,N6-acetylation at Lysine
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation
Predicted Disorder Regions	NA
DisProt Annotation
TM Helix Prediction	No TM helices
Bibliography	1. Weiskirchen, R. et al. (2001) ‘LIM-domain protein cysteine- and glycine-rich protein 2 (CRP2) is a novel marker of hepatic stellate cells and binding partner of the protein inhibitor of activated STAT1.’, The Biochemical journal, 359(Pt 3), pp. 485–96. doi: 10.1042/0264-6021:3590485.