Search by BoMiProt ID - Bomi256


Primary Information

BoMiProt ID Bomi256
Protein Name Carnitine O-palmitoyltransferase 2, mitochondrial
Organism Bos taurus
Uniprot IdQ2KJB7
Milk FractionExosome
Ref Sequence Id NP_001039354.1
Aminoacid Length 658
Molecular Weight 74483
Fasta Sequence https://www.uniprot.org/uniprot/Q2KJB7.fasta
Gene Name CPT2
Gene Id 504502
Protein Existence Status Reviewed: Experimental evidence at transcript level

Secondary Information

Presence in other biological fluids/tissue/cells located on both sides of the mitochondrial inner membrane,
Protein Function catalyse the reversible transfer of a long-chain fatty-acyl group from acyl-CoA to L-carnitine; facilitate the uptake of long-chain fatty acids into the mitochondrial matrix for oxidation. CPT2(carnitine palmitoyltransferase 2) and CACT(carnitine/acylcarnitine translocase) are crucial for mitochondrial acylcarnitine formation and export to the extracellular fluids in mFAOD.
Biochemical Properties CPT-A (in outer membrane) is more easily removed from rat liver mitochondria by digitonin extraction; CPT-A is strongly inhibited by malonyl-CoA, CPT-B is less sensitive to malonyl-CoA; As found in bovine liver mitochondria, The pl is low (pH 6.0); Km for carnitine increases below pH 7.0;
Significance in milk control lipid metabolism and helps in synthesis of medium chain fatty acids in mammary gland
PTMs N6-acetylation at Lysine
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Bibliography 1. Ramsay, R. R. et al. (1987) ‘Purification and properties of the soluble carnitine palmitoyltransferase from bovine liver mitochondria.’, The Biochemical journal, 244(2), pp. 271–8. doi: 10.1042/bj2440271. 2.Violante S, Ijlst L, Te Brinke H, Tavares de Almeida I, Wanders RJ, Ventura FV, Houten SM. Carnitine palmitoyltransferase 2 and carnitine/acylcarnitine translocase are involved in the mitochondrial synthesis and export of acylcarnitines. FASEB J. 2013 May;27(5):2039-44. doi: 10.1096/fj.12-216689. Epub 2013 Jan 15. PMID: 23322164.