Search by BoMiProt ID - Bomi2538


Primary Information

BoMiProt ID Bomi2538
Protein Name Glycogen phosphorylase, brain form
Organism Bos taurus
Uniprot IDQ3B7M9
Milk FractionExosome
Ref Sequence ID NP_001030347.1
Aminoacid Length 843
Molecular Weight 96340
FASTA Sequence Download
Gene Name PYGB
Gene ID 505560
Protein Existence Status Reviewed: Experimental evidence at transcript level

Secondary Information

Protein Function  GPBB is a novel liver progenitor cell marker, which facilitates liver progenitor cell survival under low glucose conditions and cell differentiation.
PTMs Phosphorylation of Ser-15 and Tyr residue,N-acetylation at Lys
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Significance of PTMs the activity of human bGP is redox-regulated through the formation of a disulfide bond involving a highly reactive cysteine unique to the bGP isozyme.This disulfide bond acts as a redox switch that precludes the allosteric activation of the enzyme by AMP without affecting its activation by phosphorylation.Phosphorylation of Ser-15 converts phosphorylase B (unphosphorylated) to phosphorylase A
Bibliography 1.Huang YW, Chiu CC, Liang JD, Chiou LL, Huang GT, Yu MJ, Lee HS. Brain isoform glycogen phosphorylase as a novel hepatic progenitor cell marker. PLoS One. 2015 Mar 31;10(3):e0122528. doi: 10.1371/journal.pone.0122528. PMID: 25826279; PMCID: PMC4380311. 2.Mathieu C, Duval R, Cocaign A, Petit E, Bui LC, Haddad I, Vinh J, Etchebest C, Dupret JM, Rodrigues-Lima F. An Isozyme-specific Redox Switch in Human Brain Glycogen Phosphorylase Modulates Its Allosteric Activation by AMP. J Biol Chem. 2016 Nov 11;291(46):23842-23853. doi: 10.1074/jbc.M116.757062. Epub 2016 Sep 22. PMID: 27660393; PMCID: PMC5104910.