Search by BoMiProt ID - Bomi2536


Primary Information

BoMiProt ID Bomi2536
Protein Name Pentraxin-related protein PTX3
Organism Bos taurus
Uniprot IDQ0VCG9
Milk FractionMFGM
Ref Sequence ID NP_001069727.1
Aminoacid Length 382
Molecular Weight 42021
FASTA Sequence Download
Gene Name PTX3
Gene ID 541148
Protein Existence Status Reveiwed:Experimental evidence at transcript level

Secondary Information

Protein Function PTX3, as a newly discovered acute-phase protein upon inflammation, belongs to the hs-CRP superfamily and it is highly expressed in AMI patients.
PTMs Disulfide bond formation,N-Linked Glycosylation at Asn
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Additional Comments Pentraxin related protein(PTX3) demonstrated high expression in liposarcomas as compared to normal tissues. 
Bibliography 1.Rolph MS, Zimmer S, Bottazzi B, Garlanda C, Mantovani A, Hansson GK. Production of the long pentraxin PTX3 in advanced atherosclerotic plaques. Arterioscler Thromb Vasc Biol. 2002;22(5):e10–14. 2.Willeke F, Assad A, Findeisen P, Schromm E, Grobholz R, von Gerstenbergk B, Mantovani A, Peri S, Friess HH, Post S, von Knebel Doeberitz M, Schwarzbach MH. Overexpression of a member of the pentraxin family (PTX3) in human soft tissue liposarcoma. Eur J Cancer. 2006 Oct;42(15):2639-46. doi: 10.1016/j.ejca.2006.05.035. Epub 2006 Sep 7. PMID: 16959485.