Search by BoMiProt ID - Bomi251


Primary Information

BoMiProt ID Bomi251
Protein Name Claudin-3
Organism Bos taurus
Uniprot IdQ765N9
Milk FractionExosome
Ref Sequence Id NP_991370.1
Aminoacid Length 219
Molecular Weight 23382
Fasta Sequence https://www.uniprot.org/uniprot/Q765N9.fasta
Gene Name CLDN3
Gene Id 404153
Protein Existence Status Reviewed: Experimental evidence at transcript level

Secondary Information

Protein Function tetraspan transmembrane proteins of tight junctions; regulate strength of tight junctions. The tight junction protein claudin-3 has been identified as a transcriptional target of the Wnt/β-catenin signaling pathway regulating blood-brain barrier (BBB) maturation.
Significance in milk maintain the integrity of the alveolar structure during lactation
PTMs protein kinase A in claudin-3 (Thr192, human)
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction 4TMHs; (7-29), (78-100), (121-143), (163-185)
Significance of PTMs Phosphorylation of claudin-3 may decrease the tight junction strength in ovarian cancer cells
Additional Comments In neurological disorders loss of claudin-3 immunostaining is observed at the compromised BBB and blood-cerebrospinal fluid barrier (BCSFB). 
Bibliography 1. Soma, T. et al. (2004) ‘Thr207 of claudin-5 is involved in size-selective loosening of the endothelial barrier by cyclic AMP’, Experimental Cell Research, 300(1), pp. 202–212. doi: 10.1016/j.yexcr.2004.07.012.
2. D’Souza, T., Agarwal, R. and Morin, P. J. (2005) ‘Phosphorylation of Claudin-3 at Threonine 192 by cAMP-dependent Protein Kinase Regulates Tight Junction Barrier Function in Ovarian Cancer Cells’, Journal of Biological Chemistry, 280(28), pp. 26233–26240. doi: 10.1074/jbc.M502003200.
3. Pitelka, D. R. et al. (1973) ‘CELL CONTACTS IN THE MOUSE MAMMARY GLAND: I. Normal Gland in Postnatal Development and the Secretory Cycle’, The Journal of Cell Biology, 56(3), pp. 797–818. doi: 10.1083/jcb.56.3.797. 4.Castro Dias M, Coisne C, Lazarevic I, Baden P, Hata M, Iwamoto N, Francisco DMF, Vanlandewijck M, He L, Baier FA, Stroka D, Bruggmann R, Lyck R, Enzmann G, Deutsch U, Betsholtz C, Furuse M, Tsukita S, Engelhardt B. Claudin-3-deficient C57BL/6J mice display intact brain barriers. Sci Rep. 2019 Jan 18;9(1):203. doi: 10.1038/s41598-018-36731-3. Erratum in: Sci Rep. 2019 Jul 18;9(1):10702. PMID: 30659216; PMCID: PMC6338742.