Search by BoMiProt ID - Bomi251

Primary Information

BoMiProt ID Bomi251
Protein Name Claudin-3
Organism Bos taurus
Uniprot IdQ765N9
Milk FractionExosome
Ref Sequence Id NP_991370.1
Amino Acid Lenth 219
Molecular Weight 23382
Fasta Sequence
Gene Name CLDN3
Gene Id 404153
Protein Existence Status Reviewed: Experimental evidence at transcript level

Secondry Information

Protein Function tetraspan transmembrane proteins of tight junctions; regulate strength of tight junctions
Significance in milk maintain the integrity of the alveolar structure during lactation
PTMs protein kinase A in claudin-3 (Thr192, human)
Significance of PTMs Phosphorylation of claudin-3 may decrease the tight junction strength in ovarian cancer cells
Bibliography 1. Soma, T. et al. (2004) ‘Thr207 of claudin-5 is involved in size-selective loosening of the endothelial barrier by cyclic AMP’, Experimental Cell Research, 300(1), pp. 202–212. doi: 10.1016/j.yexcr.2004.07.012.
2. D’Souza, T., Agarwal, R. and Morin, P. J. (2005) ‘Phosphorylation of Claudin-3 at Threonine 192 by cAMP-dependent Protein Kinase Regulates Tight Junction Barrier Function in Ovarian Cancer Cells’, Journal of Biological Chemistry, 280(28), pp. 26233–26240. doi: 10.1074/jbc.M502003200.
3. Pitelka, D. R. et al. (1973) ‘CELL CONTACTS IN THE MOUSE MAMMARY GLAND: I. Normal Gland in Postnatal Development and the Secretory Cycle’, The Journal of Cell Biology, 56(3), pp. 797–818. doi: 10.1083/jcb.56.3.797.