Primary Information |
|---|
| BoMiProt ID | Bomi2494 |
|---|
| Protein Name | Pyridoxal phosphate phosphatase |
|---|
| Organism | Bos taurus |
|---|
| Uniprot ID | Q3ZBF9 |
|---|
| Milk Fraction | Exosome |
|---|
| Ref Sequence ID | NP_001030207.1 |
|---|
| Aminoacid Length | 296 |
|---|
| Molecular Weight | 31749 |
|---|
| FASTA Sequence |
Download |
|---|
| Gene Name | PDXP |
|---|
| Gene ID | 506308 |
|---|
| Protein Existence Status | Reviewed: Experimental evidence at protein level |
|---|
Secondary Information |
|---|
| Protein Function | Chronophin (CIN),is initially evoked by Dox-induced RhoA signaling, resulting in a rapid phosphorylated cofilin turnover leading to actin cytoskeleton remodeling. |
|---|
| Biochemical Properties | The catalytic activity of monomeric chronophin toward PLP is strongly impaired.Dimer formation is essential for an intermolecular arginine-arginine-tryptophan stacking interaction that positions a critical histidine residue in the substrate specificity loop of chronophin for PLP coordination. |
|---|
Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| |
|---|
| Predicted Disorder Regions | NA |
|---|
| DisProt Annotation | |
|---|
| TM Helix Prediction | No TM helices |
|---|
| Bibliography | 1.Lee SJ, Park JW, Kang BS, Lee DS, Lee HS, Choi S, Kwon OS. Chronophin activation is necessary in Doxorubicin-induced actin cytoskeleton alteration. BMB Rep. 2017 Jun;50(6):335-340. doi: 10.5483/bmbrep.2017.50.6.061. PMID: 28502289; PMCID: PMC5498145. 2.Gohla A, Birkenfeld J, Bokoch GM. Chronophin, a novel HAD-type serine protein phosphatase, regulates cofilin-dependent actin dynamics. Nat Cell Biol. 2005 Jan;7(1):21-9. doi: 10.1038/ncb1201. Epub 2004 Dec 5. PMID: 15580268. |
|---|
