Primary Information |
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BoMiProt ID | Bomi2470 |
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Protein Name | Pyridoxal kinase |
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Organism | Bos taurus |
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Uniprot ID | Q0II59 |
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Milk Fraction | MFGM, Exosome |
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Ref Sequence ID | NP_001069119.1 |
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Aminoacid Length | 312 |
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Molecular Weight | 34817 |
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FASTA Sequence |
Download |
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Gene Name | PDXK |
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Gene ID | 514168 |
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Protein Existence Status | Reviewed: Experimental evidence at transcript level |
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Secondary Information |
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Protein Function | PDXK utilizes inactive forms of vitamin B6 (pyridoxal [PL], pyridoxine, and pyridoxamine) and ATP as substrates, producing PLP along with the byproduct ADP. |
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PTMs | N-acetylation at Methionine,Phosphorylation at Serine |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
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Predicted Disorder Regions | NA |
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DisProt Annotation | |
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TM Helix Prediction | No TM helices |
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Bibliography | Kasaragod VB, Pacios-Michelena A, Schaefer N, Zheng F, Bader N, Alzheimer C, Villmann C, Schindelin H. Pyridoxal kinase inhibition by artemisinins down-regulates inhibitory neurotransmission. Proc Natl Acad Sci U S A. 2020 Dec 29;117(52):33235-33245. doi: 10.1073/pnas.2008695117. Epub 2020 Dec 14. PMID: 33318193; PMCID: PMC7777086. |