Primary Information |
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| BoMiProt ID | Bomi2448 |
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| Protein Name | Nuclear pore complex protein Nup93 |
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| Organism | Bos taurus |
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| Uniprot ID | A5PJZ5 |
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| Milk Fraction | Exosome |
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| Ref Sequence ID | NP_001092391.1 |
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| Aminoacid Length | 819 |
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| Molecular Weight | 93458 |
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| FASTA Sequence |
Download |
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| Gene Name | NUP93 |
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| Gene ID | 510004 |
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| Protein Existence Status | Reviewed: Experimental evidence at transcript level |
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Secondary Information |
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| Protein Function | Nucleoporin 93 (Nup93), components of nuclear pore complex (NPC), plays an important role in RLR-mediated antiviral responses.Nup93 regulates antiviral innate immunity by enhancing TBK1 activity and IRF3 nuclear translocation. |
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| Biochemical Properties | Nup93 is essential for NPC formation and located at inner-ring Nups. N-terminal coiled-coil region in Nup93 mediates the recruitment of Nup62 complex and establishment of the permeability barrier and transport competency of the NPC. C-terminal region of Nup93 contains the NIC96 domain which has two alpha-helical (α) regions and is blinkered by beta-sheet (β) |
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| PTMs | Phosphorylation at Serine |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Additional Comments | Nup93 overexpression enhanced TBK1-mediated IFNβ promoter activation. |
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| Bibliography | 1.R. Sachdev, C. Sieverding, M. Flötenmeyer, W. Antonin.The C-terminal domain of Nup93 is essential for assembly of the structural backbone of nuclear pore complexes.Mol. Biol. Cell, 23 (4) (2012), pp. 740-749. 2.Monwan W, Kawasaki T, Hasan MZ, Ori D, Kawai T. Identification of nucleoporin 93 (Nup93) that mediates antiviral innate immune responses. Biochem Biophys Res Commun. 2020 Jan 22;521(4):1077-1082. doi: 10.1016/j.bbrc.2019.11.035. Epub 2019 Nov 14. PMID: 31733835. |
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