Search by BoMiProt ID - Bomi2447


Primary Information

BoMiProt ID Bomi2447
Protein Name Nuclear migration protein nudC
Organism Bos taurus
Uniprot IDQ17QG2
Milk FractionExosome
Ref Sequence ID NP_001069075.1
Aminoacid Length 332
Molecular Weight 38243
FASTA Sequence Download
Gene Name NUDC
Gene ID 513277
Protein Existence Status Reviewed: Experimental evidence at transcript level

Secondary Information

Protein Function NudC is a highly conserved protein necessary for cytoplasmic dynein-mediated nuclear migration in Aspergillus nidulans. NudC interacts genetically with Aspergillus NudF and physically with its mammalian orthologue Lis1, which is crucial for nuclear and neuronal migration during brain development.
Biochemical Properties NudC contains a binding site for the mitotic kinase Plk1 and two Plk1 phosphorylation sites within its C-terminal domain
PTMs N6-acetylation at Lysine, Phosphorylation at Ser/Thr
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
Predicted Disorder Regions 65-108,126-171
DisProt Annotation
TM Helix Prediction No TM helices
Significance of PTMs Phosphorylation on Ser-275,327 is necessary for correct formation of mitotic spindles and chromosome separation during mitosis. 
Additional Comments  In Aspergillus, the mutant NudC3 leads to a nuclear migration defect similar to NudA (dynein heavy chain gene homologue) mutations and knock out.
Bibliography 1.Extragenic suppressors of nudC3, a mutation that blocks nuclear migration in Aspergillus nidulans.Chiu YH, Morris NR.Genetics. 1995 Oct; 141(2):453-64. 2.A role for Plk1 phosphorylation of NudC in cytokinesis. Zhou T, Aumais JP, Liu X, Yu-Lee LY, Erikson RL.Dev Cell. 2003 Jul; 5(1):127-38.