Primary Information |
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BoMiProt ID | Bomi2447 |
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Protein Name | Nuclear migration protein nudC |
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Organism | Bos taurus |
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Uniprot ID | Q17QG2 |
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Milk Fraction | Exosome |
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Ref Sequence ID | NP_001069075.1 |
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Aminoacid Length | 332 |
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Molecular Weight | 38243 |
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FASTA Sequence |
Download |
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Gene Name | NUDC |
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Gene ID | 513277 |
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Protein Existence Status | Reviewed: Experimental evidence at transcript level |
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Secondary Information |
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Protein Function | NudC is a highly conserved protein necessary for cytoplasmic dynein-mediated nuclear migration in Aspergillus nidulans. NudC interacts genetically with Aspergillus NudF and physically with its mammalian orthologue Lis1, which is crucial for nuclear and neuronal migration during brain development. |
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Biochemical Properties | NudC contains a binding site for the mitotic kinase Plk1 and two Plk1 phosphorylation sites within its C-terminal domain |
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PTMs | N6-acetylation at Lysine, Phosphorylation at Ser/Thr |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
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Predicted Disorder Regions | 65-108,126-171 |
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DisProt Annotation | |
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TM Helix Prediction | No TM helices |
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Significance of PTMs | Phosphorylation on Ser-275,327 is necessary for correct formation of mitotic spindles and chromosome separation during mitosis. |
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Additional Comments | In Aspergillus, the mutant NudC3 leads to a nuclear migration defect similar to NudA (dynein heavy chain gene homologue) mutations and knock out. |
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Bibliography | 1.Extragenic suppressors of nudC3, a mutation that blocks nuclear migration in Aspergillus nidulans.Chiu YH, Morris NR.Genetics. 1995 Oct; 141(2):453-64. 2.A role for Plk1 phosphorylation of NudC in cytokinesis.
Zhou T, Aumais JP, Liu X, Yu-Lee LY, Erikson RL.Dev Cell. 2003 Jul; 5(1):127-38. |