Search by BoMiProt ID - Bomi2442


Primary Information

BoMiProt ID Bomi2442
Protein Name Nurim
Organism Bos taurus
Uniprot IDQ32LM8
Milk FractionMFGM
Ref Sequence ID NP_001032685.1
Aminoacid Length 262
Molecular Weight 29638
FASTA Sequence Download
Gene Name NRM
Gene ID 511167
Protein Existence Status Reviewed: Experimental evidence at protein level

Secondary Information

Protein Function INM protein Nurim plays an important role in the suppression of apoptosis.
Biochemical Properties The first four transmembrane segments (residues 4 to 26, 58 to 82, 100 to 122 and 142 to 164) of Nurim a were predicted. Both HMMtop and TMpred predictions maintained the organization of residues 203 to 240; however, in one prediction(HMMtop), the fifth domain is predicted to span the membrane twice with a hairpin turn.Previous research has revealed that both the N- and C-terminal ends of Nurim a are located on the luminal side of the membrane.Nurim a possesses a six-TMD topology and Nurim b is a five-TMD protein as a large part of the missing exon 3 (residues 111 to 169) is predicted to form TMD4.
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction 3TMHS; (4-26),(99-117),(136-158)
Bibliography 1.Chen H, Chen K, Chen J, Cheng H, Zhou R. The integral nuclear membrane protein nurim plays a role in the suppression of apoptosis. Curr Mol Med. 2012 Dec;12(10):1372-82. doi: 10.2174/156652412803833571. PMID: 23092226. 2.Hofemeister, H. and O'Hare, P., 2005. Analysis of the localization and topology of nurim, a polytopic protein tightly associated with the inner nuclear membrane. J Biol Chem 280, 2512-21. 3.Zhang W, Bai T, Zhang S, Xu S, Chen H, Li C. Isoforms of the nuclear envelope protein Nurim are differentially expressed during heart development in mice. Gene. 2017 Sep 5;627:123-128. doi: 10.1016/j.gene.2017.06.009. Epub 2017 Jun 7. PMID: 28600179.