Primary Information |
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BoMiProt ID | Bomi244 |
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Protein Name | CD63 antigen |
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Organism | Bos taurus |
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Uniprot ID | Q9XSK2 |
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Milk Fraction | Exosome |
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Ref Sequence ID | NP_991372.1 |
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Aminoacid Length | 237 |
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Molecular Weight | 25752 |
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FASTA Sequence |
Download |
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Gene Name | CD63 |
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Gene ID | 404156 |
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Protein Existence Status | Reviewed: Experimental evidence at transcript level |
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Secondary Information |
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Presence in other biological fluids/tissue/cells | intracellular tetraspanin and
is mainly localized to late endosomal and lysosomal compartments; component
of Weibel-Palade bodies which store and
secrete von Willebrand factor |
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Protein Function | involved in vascular cell adhesion; inhibit monocyte and neutrophil adhesion to serum-coated
substratum and EC layer, respectively; physically associates with several integrins such as α3ß1,
α6ß1, and αLß2; regulate exocytosis at
the cellular level; CD63 inhibits IgE-mediated release of
histamine in basophils; likely regulates cell migration; bind syntenin-1, a PDZ domain-containing
adapter protein |
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PTMs | glycosylated: N glycosyated in the extracellular loop |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
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Predicted Disorder Regions | NA |
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DisProt Annotation | |
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TM Helix Prediction | 4TMHs; (13-35), (50-72), (85-107), (205-227) |
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Significance of PTMs | highly resistant
to lysosomal enzymes and thus may be one of the
glycoproteins protecting and stabilizing the lysosomal
membrane |
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Bibliography | 1. Vischer, U. M. and Wagner, D. D. (1993) ‘CD63 is a component of Weibel-Palade bodies of human endothelial cells.’, Blood, 82(4), pp. 1184–91. Available at: http://www.ncbi.nlm.nih.gov/pubmed/8353283 (Accessed: 5 October 2019). 2. Skubitz, K. M. et al. (1996) ‘CD63 associates with tyrosine kinase activity and CD11/CD18, and transmits an activation signal in neutrophils.’, Journal of immunology (Baltimore, Md. : 1950), 157(8), pp. 3617–26. Available at: http://www.ncbi.nlm.nih.gov/pubmed/8871662 (Accessed: 5 October 2019). 3. Hotta, H. et al. (1992) ‘Genomic structure of the ME491/CD63 antigen gene and functional analysis of the 5’-flanking regulatory sequences.’, Biochemical and biophysical research communications, 185(1), pp. 436–42. doi: 10.1016/s0006-291x(05)81004-6. |