Search by BoMiProt ID - Bomi244


Primary Information

BoMiProt ID Bomi244
Protein Name CD63 antigen
Organism Bos taurus
Uniprot IDQ9XSK2
Milk FractionExosome
Ref Sequence ID NP_991372.1
Aminoacid Length 237
Molecular Weight 25752
FASTA Sequence Download
Gene Name CD63
Gene ID 404156
Protein Existence Status Reviewed: Experimental evidence at transcript level

Secondary Information

Presence in other biological fluids/tissue/cells intracellular tetraspanin and is mainly localized to late endosomal and lysosomal compartments; component of Weibel-Palade bodies which store and secrete von Willebrand factor
Protein Function involved in vascular cell adhesion; inhibit monocyte and neutrophil adhesion to serum-coated substratum and EC layer, respectively; physically associates with several integrins such as α3ß1, α6ß1, and αLß2; regulate exocytosis at the cellular level; CD63 inhibits IgE-mediated release of histamine in basophils; likely regulates cell migration; bind syntenin-1, a PDZ domain-containing adapter protein
PTMs glycosylated: N glycosyated in the extracellular loop
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction 4TMHs; (13-35), (50-72), (85-107), (205-227)
Significance of PTMs highly resistant to lysosomal enzymes and thus may be one of the glycoproteins protecting and stabilizing the lysosomal membrane
Bibliography 1. Vischer, U. M. and Wagner, D. D. (1993) ‘CD63 is a component of Weibel-Palade bodies of human endothelial cells.’, Blood, 82(4), pp. 1184–91. Available at: http://www.ncbi.nlm.nih.gov/pubmed/8353283 (Accessed: 5 October 2019).
2. Skubitz, K. M. et al. (1996) ‘CD63 associates with tyrosine kinase activity and CD11/CD18, and transmits an activation signal in neutrophils.’, Journal of immunology (Baltimore, Md. : 1950), 157(8), pp. 3617–26. Available at: http://www.ncbi.nlm.nih.gov/pubmed/8871662 (Accessed: 5 October 2019).
3. Hotta, H. et al. (1992) ‘Genomic structure of the ME491/CD63 antigen gene and functional analysis of the 5’-flanking regulatory sequences.’, Biochemical and biophysical research communications, 185(1), pp. 436–42. doi: 10.1016/s0006-291x(05)81004-6.