Primary Information
BoMiProt ID	Bomi2436
Protein Name	NHL repeat-containing protein 2
Organism	Bos taurus
Uniprot ID	A4IF69
Milk Fraction	Exosome
Ref Sequence ID	NP_001077192.1
Aminoacid Length	726
Molecular Weight	79314
FASTA Sequence	Download
Gene Name	NHLRC2
Gene ID	534327
Protein Existence Status	Reviewed: Experimental evidence at transcript level
Secondary Information
Protein Function	NHL-repeat-containing protein 2 (NHLRC2) thioredoxin-like domain protein is cleaved by caspase-8 in ROS-induced apoptosis in the HCT116 human colon cancer cell line.
Biochemical Properties	NHL-repeat-containing protein 2 (NHLRC2) is a 79 kDa protein of 726 amino acids that consists of the N-terminal Trx-like domain and a C-terminal NHL (NCL-1, HT2A, and LIN-41)-repeat domain. The NHL-repeat domains have been proposed to form β-propeller structures, similar to those of the WD40-repeat domain, suggesting their functions in protein–protein interactions.
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation
Predicted Disorder Regions	NA
DisProt Annotation
TM Helix Prediction	No TM helices
Bibliography	1.Nishi K, Iwaihara Y, Tsunoda T, Doi K, Sakata T, Shirasawa S, Ishikura S. ROS-induced cleavage of NHLRC2 by caspase-8 leads to apoptotic cell death in the HCT116 human colon cancer cell line. Cell Death Dis. 2017 Dec 14;8(12):3218. doi: 10.1038/s41419-017-0006-7. PMID: 29242562; PMCID: PMC5870588. 2.Sensor domain of the Mycobacterium tuberculosis receptor Ser/Thr protein kinase, PknD, forms a highly symmetric beta propeller.Good MC, Greenstein AE, Young TA, Ng HL, Alber T.J Mol Biol. 2004 May 28; 339(2):459-69. 3.A novel repeat domain that is often associated with RING finger and B-box motifs.Slack FJ, Ruvkun G;Trends Biochem Sci. 1998 Dec; 23(12):474-5.