Search by BoMiProt ID - Bomi2433


Primary Information

BoMiProt ID Bomi2433
Protein Name Adaptin ear-binding coat-associated protein 1
Organism Bos taurus
Uniprot IDQ3T093
Milk FractionExosome
Ref Sequence ID NP_001029383.1
Aminoacid Length 275
Molecular Weight 29597
FASTA Sequence Download
Gene Name NECAP1
Gene ID 504449
Protein Existence Status Reveiwed:Experimental evidence at transcript level

Secondary Information

Presence in other biological fluids/tissue/cells found primarily in tissues from the central nervous system; Adaptin ear-binding coat-associated protein 1 is primarily present in brain, while the homolog Adaptin ear-binding coat-associated protein 2 is present ubiquitously
Protein Function new family of clathrin accessory proteins identified through a proteomic analysis of clathrin-coated vesicles (CCVs) from the brain; plays a role in clathrin-mediated neuronal endocytosis, including a role in presynaptic endocytosis; found to be associated with synapses and purified synaptic vesicles; NECAP 1 regulates the endocytosis of AP-2 interacting proteins, including transferrin and synaptotagmin
Biochemical Properties bind to AP-2 through a newly characterized motif consisting of four amino acids;
Linking IDs Bomi67
Bibliography 1. Murshid, A., Srivastava, A., Kumar, R., & Presley, J. F. (2006). Characterization of the localization and function of NECAP 1 in neurons. Journal of Neurochemistry, 98(6), 1746–1762. https://doi.org/10.1111/j.1471-4159.2006.04066.
2. Ritter, B., Murphy, S., Dokainish, H., Girard, M., Gudheti, M. V., Kozlov, G., … McPherson, P. S. (2013). NECAP 1 Regulates AP-2 Interactions to Control Vesicle Size, Number, and Cargo During Clathrin-Mediated Endocytosis. PLoS Biology, 11(10). https://doi.org/10.1371/journal.pbio.1001670.
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
Predicted Disorder Regions 166-190,215-275
DisProt Annotation
TM Helix Prediction No TM helices