Primary Information | |
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BoMiProt ID | Bomi2433 |
Protein Name | Adaptin ear-binding coat-associated protein 1 |
Organism | Bos taurus |
Uniprot ID | Q3T093 |
Milk Fraction | Exosome |
Ref Sequence ID | NP_001029383.1 |
Aminoacid Length | 275 |
Molecular Weight | 29597 |
FASTA Sequence | Download |
Gene Name | NECAP1 |
Gene ID | 504449 |
Protein Existence Status | Reveiwed:Experimental evidence at transcript level |
Secondary Information | |
Presence in other biological fluids/tissue/cells | found primarily in tissues from the central nervous system; Adaptin ear-binding coat-associated protein 1 is primarily present in brain, while the homolog Adaptin ear-binding coat-associated protein 2 is present ubiquitously |
Protein Function | new family of clathrin accessory proteins identified through a proteomic analysis of clathrin-coated vesicles (CCVs) from the brain; plays a role in clathrin-mediated neuronal endocytosis, including a role in presynaptic endocytosis; found to be associated with synapses and purified synaptic vesicles; NECAP 1 regulates the endocytosis of AP-2 interacting proteins, including transferrin and synaptotagmin |
Biochemical Properties | bind to AP-2 through a newly characterized motif consisting of four amino acids; |
Linking IDs | Bomi67 |
Bibliography | 1. Murshid, A., Srivastava, A., Kumar, R., & Presley, J. F. (2006). Characterization of the localization and function of NECAP 1 in neurons. Journal of Neurochemistry, 98(6), 1746–1762. https://doi.org/10.1111/j.1471-4159.2006.04066. 2. Ritter, B., Murphy, S., Dokainish, H., Girard, M., Gudheti, M. V., Kozlov, G., … McPherson, P. S. (2013). NECAP 1 Regulates AP-2 Interactions to Control Vesicle Size, Number, and Cargo During Clathrin-Mediated Endocytosis. PLoS Biology, 11(10). https://doi.org/10.1371/journal.pbio.1001670. |
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation | |
Predicted Disorder Regions | 166-190,215-275 |
DisProt Annotation | |
TM Helix Prediction | No TM helices |